Evidence map›Paper›PMID 35817953›Full record

ReviewNPJ digital medicine2022

The promise of machine learning applications in solid organ transplantation.

Neta Gotlieb, Amirhossein Azhie, Divya Sharma, Ashley Spann, Nan-Ji Suo, Jason Tran, Ani Orchanian-Cheff, Bo Wang, Anna Goldenberg, Michael Chassé and 5 more

Abstract readReview
In one paragraph

Review in NPJ digital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  9. A data-driven framework for fair and efficient organ transplantation using gradient boosting and adaptive genetic allocation.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Neta GotliebAjmera Transplant Program, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3827-8262
Amirhossein AzhieAjmera Transplant Program, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-6393-9064
Divya SharmaDepartment of Gastroenterology, Toronto General Hospital Research Institute, Toronto, ON, Canada.
Ashley SpannDivision of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1278-7712
Nan-Ji SuoDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Jason TranAjmera Transplant Program, University Health Network, Toronto, ON, Canada.
Ani Orchanian-CheffLibrary and Information Services, University Health Network, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-9943-2692
Bo WangVector Institute for Artificial Intelligence, Toronto, ON, Canada.
Anna GoldenbergVector Institute for Artificial Intelligence, Toronto, ON, Canada.
Michael ChasséDepartment of Medicine (Critical Care), University of Montreal Hospital, Montréal, QC, Canada.
Heloise CardinalCanadian Donation and Transplantation Research Program, Data and Innovation Expert Group, Toronto, ON, Canada.
Joseph Paul CohenCanadian Donation and Transplantation Research Program, Data and Innovation Expert Group, Toronto, ON, Canada.
Andrea LodiCanadian Donation and Transplantation Research Program, Data and Innovation Expert Group, Toronto, ON, Canada.
Melanie DieudeCanadian Donation and Transplantation Research Program, Data and Innovation Expert Group, Toronto, ON, Canada.
Mamatha BhatAjmera Transplant Program, University Health Network, Toronto, ON, Canada. mamatha.bhat@uhn.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Solid-organ transplantation is a life-saving treatment for end-stage organ disease in highly selected patients. Alongside the tremendous progress in the last several decades, new challenges have emerged. The growing disparity between organ demand and supply requires optimal patient/donor selection and matching. Improvements in long-term graft and patient survival require data-driven diagnosis and management of post-transplant complications. The growing abundance of clinical, genetic, radiologic, and metabolic data in transplantation has led to increasing interest in applying machine-learning (ML) tools that can uncover hidden patterns in large datasets. ML algorithms have been applied in predictive modeling of waitlist mortality, donor-recipient matching, survival prediction, post-transplant complications diagnosis, and prediction, aiming to optimize immunosuppression and management. In this review, we provide insight into the various applications of ML in transplant medicine, why these were used to evaluate a specific clinical question, and the potential of ML to transform the care of transplant recipients. 36 articles were selected after a comprehensive search of the following databases: Ovid MEDLINE; Ovid MEDLINE Epub Ahead of Print and In-Process & Other Non-Indexed Citations; Ovid Embase; Cochrane Database of Systematic Reviews (Ovid); and Cochrane Central Register of Controlled Trials (Ovid). In summary, these studies showed that ML techniques hold great potential to improve the outcome of transplant recipients. Future work is required to improve the interpretability of these algorithms, ensure generalizability through larger-scale external validation, and establishment of infrastructure to permit clinical integration.

Identifiers

PMID35817953
PMCPMC9273640

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.