Evidence map›Paper›PMID 35817954›Full record

ArticleBritish journal of pharmacology2022

Selective block of adenosine A

Elisabetta Coppi, Alasdair J Gibb

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Adenosine ANeural regeneration research · 2024
    Review
  3. Review
  4. Selective block of adenosine ABritish journal of pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Elisabetta CoppiDepartment of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
Alasdair J GibbDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
University College London · GBUniversity of Florence · IT

Funding

Biotechnology and Biological Sciences Research Council BB/D015782/1Parkinson's UK H-0902Wellcome Trust
6 · The paper itself

Abstract

background and purposeIschaemia is known to cause massive neuronal depolarization, termed anoxic depolarization (AD), due to energy failure and loss of membrane ion gradients. The neuromodulator adenosine accumulates extracellularly during ischaemia and activates four metabotropic receptors: A EXPERIMENTAL APPROACH: We performed patch-clamp recordings of MSNs in rat striatal slices subjected to oxygen and glucose deprivation (OGD) to investigate the effects of A KEY

resultsOur data indicate that the A CONCLUSION AND IMPLICATIONS: Adenosine, released during striatal OGD, activates A

Indexed as

GlucoseOxygenAdenosineAnimalsGlutamic AcidIon ChannelsIschemiaLigandsNeuronsRatsRats, WistarReceptor, Adenosine A2ATetrodotoxinAdenosineGlucoseGlutamic AcidIon ChannelsLigandsOxygenReceptor, Adenosine A2ATetrodotoxinadenosine A2A receptoranoxic depolarizationbrain ischaemiaK+ currentsmediium spiny neuronsspontaneous and miniature excitatory postsynaptic currents

Identifiers

PMID35817954
PMCPMC9796695
OpenAlexW4285025824

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.