ArticleJournal of the American Medical Informatics Association : JAMIA2022
HL7 FHIR-based tools and initiatives to support clinical research: a scoping review.
Article in Journal of the American Medical Informatics Association : JAMIA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Mapping the path to clinical implementation of multi-omics.Nature genetics · 2026Review
- Benchmarking Fast Healthcare Interoperability Resources-Based Analytics: Quantitative Study of RESTful Server Queries and Big Data Engines.JMIR medical informatics · 2026Article
- Automated video-based AVPU assessment within a FHIR-enabled clinical decision support framework.Scientific reports · 2026Article
- Article
- FHIR-AgentEval: A Modular Sandbox for Benchmarking Clinical LLM Agents with an Evaluation of Memory-Augmented Configurations.Research square · 2026Article
- Model-Informed Precision Dosing: Conceptual Framework for Therapeutic Drug Monitoring Integrating Machine Learning and Artificial Intelligence Within Population Health Informatics.Journal of personalized medicine · 2026Review
- Deconstructing the Interoperability Stack: A Comparative Technical Analysis of HL7 v2, CDA, and the FHIR Resource Framework.Computational and structural biotechnology journal · 2026Review
- A standards-based approach to digital health research: implementing the people heart study.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Article
- Advancing Compliance with HIPAA and GDPR in Healthcare: A Blockchain-Based Strategy for Secure Data Exchange in Clinical Research Involving Private Health Information.Healthcare (Basel, Switzerland) · 2025Review
- Article
- A prototype ETL pipeline that uses HL7 FHIR RDF resources when deploying pure functions to enrich knowledge graph patient data.Journal of biomedical semantics · 2025Article
- Informatics at the Frontier of Cancer Research.Cancer research · 2025Review
- Machine Learning and Artificial Intelligence in Intensive Care Medicine: Critical Recalibrations from Rule-Based Systems to Frontier Models.Journal of clinical medicine · 2025Review
- Data Interoperability in Context: The Importance of Open-Source Implementations When Choosing Open Standards.Journal of medical Internet research · 2025Article
- An ontology-based rare disease common data model harmonising international registries, FHIR, and Phenopackets.Scientific data · 2025Article
- The Venus score for the assessment of the quality and trustworthiness of biomedical datasets.BioData mining · 2025Article
- New implementation of data standards for AI in oncology: Experience from the EuCanImage project.GigaScience · 2025Article
- Achieving a rapid and continuous learning health system requires socio-technical harmonization of research and operational IT.npj health systems · 2025Review
- Big data research is everyone's research-Making epilepsy data science accessible to the global community: Report of the ILAE big data commission.Epileptic disorders : international epilepsy journal with videotape · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesThe HL7® fast healthcare interoperability resources (FHIR®) specification has emerged as the leading interoperability standard for the exchange of healthcare data. We conducted a scoping review to identify trends and gaps in the use of FHIR for clinical research. MATERIALS AND
methodsWe reviewed published literature, federally funded project databases, application websites, and other sources to discover FHIR-based papers, projects, and tools (collectively, "FHIR projects") available to support clinical research activities.
resultsOur search identified 203 different FHIR projects applicable to clinical research. Most were associated with preparations to conduct research, such as data mapping to and from FHIR formats (n = 66, 32.5%) and managing ontologies with FHIR (n = 30, 14.8%), or post-study data activities, such as sharing data using repositories or registries (n = 24, 11.8%), general research data sharing (n = 23, 11.3%), and management of genomic data (n = 21, 10.3%). With the exception of phenotyping (n = 19, 9.4%), fewer FHIR-based projects focused on needs within the clinical research process itself. DISCUSSION: Funding and usage of FHIR-enabled solutions for research are expanding, but most projects appear focused on establishing data pipelines and linking clinical systems such as electronic health records, patient-facing data systems, and registries, possibly due to the relative newness of FHIR and the incentives for FHIR integration in health information systems. Fewer FHIR projects were associated with research-only activities.
conclusionThe FHIR standard is becoming an essential component of the clinical research enterprise. To develop FHIR's full potential for clinical research, funding and operational stakeholders should address gaps in FHIR-based research tools and methods.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.