Evidence map›Paper›PMID 35818428›Full record

ArticleJournal of ginseng research2022

Syringaresinol derived from

Wooram Choi, Hyun Soo Kim, Sang Hee Park, Donghyun Kim, Yong Deog Hong, Ji Hye Kim, Jae Youl Cho

Open access · goldAbstract read
In one paragraph

Article in Journal of ginseng research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 50 citations in OpenAlex.

  1. Syringaresinol Attenuates Aging-Associated Ferroptosis-Relevant Stress Through an HIF-1α-GPX4 Defense Axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Life (Basel, Switzerland) · 2026
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  11. Anti-Colorectal Cancer Activity ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Wooram ChoiDepartment of Integrative Biotechnology, And Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Republic of Korea.
Hyun Soo KimResearch and Innovation Center, AMOREPACIFIC, Yongin, Republic of Korea.
Sang Hee ParkDepartment of Biocosmetics, Sungkyunkwan University, Suwon, Republic of Korea.
Donghyun KimResearch and Innovation Center, AMOREPACIFIC, Yongin, Republic of Korea.
Yong Deog HongResearch and Innovation Center, AMOREPACIFIC, Yongin, Republic of Korea.
Ji Hye KimDepartment of Integrative Biotechnology, And Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Republic of Korea.
Jae Youl ChoDepartment of Integrative Biotechnology, And Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, Republic of Korea.
Sungkyunkwan University · KRAmorepacific (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In aged skin, reactive oxygen species (ROS) induces degradation of the extracellular matrix (ECM), leading to visible aging signs. Collagens in the ECM are cleaved by matrix metalloproteinases (MMPs). Syringaresinol (SYR), isolated from Methods: The preventive effect of SYR on skin aging was investigated in human HaCaT keratinocytes in the presence of H Results: SYR significantly reduced gene expression and protein levels of MMP-9 and -2 in both H Conclusion: SYR showed antioxidant activity and up-regulated autophagy activity in H

Indexed as

3-MA, 3-MethyladenineABTS, 2,2′-azino-bis-3-ethylbenzothiazoline-6-sulfonic acidAnti-agingAntioxidantAutophagyCMA, chaperone-mediated autophagyDMEM, Dulbecco's Modified Eagle's mediumDMSO, dimethyl sulfoxideDPPH, 2,2 diphenyl-1-picrylhydrazylECM, extracellular matrixFBS, fetal bovine serumFoxO3a, Forkhead box O3MAPK, mitogen-activated protein kinaseMMP, matrix metalloproteinasePanax ginseng berryPBS, phosphate-buffered salinePCR, polymerase chain reactionROS, reactive oxygen speciesSyringaresinolSYR, SyringaresinolUV, ultraviolet

Identifiers

PMID35818428
PMCPMC9270644
OpenAlexW3193740231

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.