ReviewAmerican journal of reproductive immunology (New York, N.Y. : 1989)2022
Genetics, epigenetics, and transcriptomics of preterm birth.
Review in American journal of reproductive immunology (New York, N.Y. : 1989), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The intergenerational association of preterm birth: A systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Pooled it
- Multi-Omics for Mothers and Infants (MOMI) Consortium: a global initiative to study adverse pregnancy outcomes.Journal of global health · 2026Article
- Identifying epigenetic and microbial biomarkers for preterm birth using DNA methylation and gut microbiome data.Frontiers in cellular and infection microbiology · 2026Article
- Association of maternal VDR and VDBP gene polymorphisms with spontaneous preterm birth risks: a nested case-control study in China.BMC pregnancy and childbirth · 2025Article
- The Mediating Role of Social and Environmental Determinants of Health in the Association Between Race and Preterm Birth Risk.Journal of women's health (2002) · 2025Article
- Multi-parametric quantitative evaluation of murine cervical remodeling during pregnancy and postpartum.Scientific reports · 2025Article
- Single-nucleus RNA sequencing reveals distinct pathophysiological trophoblast signatures in spontaneous preterm birth subtypes.Cell & bioscience · 2025Article
- Long-term health outcomes of preterm birth: a narrative review.Frontiers in pediatrics · 2025Review
- Regulation of term and preterm labor: genetics and epigenetics.Frontiers in genetics · 2025Article
- Barrier genes are associated with preterm birth.Frontiers in medicine · 2025Article
- Epigenetic profiling of preterm birth: a dual-tissue methylation patterns using long-read sequencing.Frontiers in epigenetics and epigenomics · 2025Article
- Vaginal Microbiome and the Risk of Preterm Birth in Women Living With HIV: A Scoping Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA)-Should They Be Mandatory Supplements in Pregnancy?Biomedicines · 2024Review
- Article
- Recent Advances in Genomic Studies of Gestational Duration and Preterm Birth.Clinics in perinatology · 2024Review
- Impact of prematurity on LINE-1 promoter methylation.Epigenomics · 2024Article
- Trends and risk of recurrent preterm birth in pregnancy cohorts in rural Bangladesh, 1990-2019.BMJ global health · 2023Article
- Article
- Early-to-mid pregnancy sleep and circadian markers in relation to birth outcomes: An epigenetics pilot study.Chronobiology international · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Preterm birth contributes significantly to neonatal mortality and morbidity. Despite its global significance, there has only been limited progress in preventing preterm birth. Spontaneous preterm birth (sPTB) results from a wide variety of pathological processes. Although many non-genetic risk factors influence the timing of gestation and labor, compelling evidence supports the role of substantial genetic and epigenetic influences and their interactions with the environment contributing to sPTB. To investigate a common and complex disease such as sPTB, various approaches such as genome-wide association studies, whole-exome sequencing, transcriptomics, and integrative approaches combining these with other 'omics studies have been used. However, many of these studies were typically small or focused on a single ethnicity or geographic region with limited data, particularly in populations at high risk for sPTB, or lacked a robust replication. These studies found many genes involved in the inflammation and immunity-related pathways that may affect sPTB. Recent studies also suggest the role of epigenetic modifications of gene expression by the environmental signals as a potential contributor to the risk of sPTB. Future genetic studies of sPTB should continue to consider the contributions of both maternal and fetal genomes as well as their interaction with the environment.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.