Evidence mapPaperPMID 35820563Full record

Observational studyDiabetes research and clinical practice2022

Greater intake of the MEDI diet is associated with better cognitive trajectory in older adults with type 2 diabetes.

Roni Lotan, Ramit Ravona-Springer, Jacob Shakked, Hung-Mo Lin, Yuxia Ouyang, Danit R Shahar, Sharon Bezalel, Puja Agarwal, Klodian Dhana, Anthony Heymann and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Diabetes research and clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Article
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roni LotanThe Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel. Electronic address: roni.lotan@mail.huji.ac.il.
Ramit Ravona-SpringerThe Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel; Department of Psychiatry, Sheba Medical Center, Tel HaShomer, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Jacob ShakkedSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hung-Mo LinDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Yuxia OuyangDepartment of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Danit R ShaharThe S. Daniel Abraham International Center for Health and Nutrition, Department of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Sharon BezalelThe S. Daniel Abraham International Center for Health and Nutrition, Department of Public Health, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Puja AgarwalRush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Klodian DhanaRush Institute of Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
Anthony HeymannSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Maccabi Health Services, Tel Aviv, Israel.
Mary SanoJames J. Peters VA Medical Center, Bronx, NY, USA; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michal Schnaider BeeriThe Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel HaShomer, Israel; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Systemic and dietary advanced glycation end products in type 2 diabetes-related cognitive decline and incident dementia: effects on Alzheimer's pathology and cerebrovascular diseaseR01AG061093 · NIA · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI SCHNAIDER BEERI, MICHAL · 2019 to 2024
$4.3M
NIA NIH HHS R01 AG061093
6 · The paper itself

Abstract

aimsTo determine associations of three dietary patterns (Mediterranean (MEDI) diet, the Dietary Approaches to Stop Hypertension (DASH) diet and the Mediterranean- DASH Intervention for Neurodegenerative Delay (MIND) diet) with cognitive decline in older adults with type 2 diabetes mellitus (T2D).

methodsThis is a longitudinal observational study. Participants (N = 960) from the Israel Diabetes and Cognitive Decline (IDCD) study were included in this study. A multivariable-adjusted model including all three dietary patterns concurrently was developed to investigate their independent effect on cognitive decline.

resultsThe mean follow up was 4.1 ± 2.1 years. While high adherence to both the MIND and the MEDI diet was associated with a slower decline, in the multivariable model only the associations of higher MEDI diet intake with greater decline in global cognition and in executive functions remained significant (β = 0.013, SE = 0.006; P = 0.042; β = 0.001, SE = 0.008, Pv = 0.023 respectively).

conclusionsIn older adults with T2D, adherence to the MEDI is related to better cognitive trajectory. Diet is a meaningful factor in the path linking T2D and cognition.

Indexed as

Cognition DisordersCognitive DysfunctionDiabetes Mellitus, Type 2Diet, MediterraneanAgedCognitionHumansCognitive declineDietary patternsOlder adultsType 2 diabetes

Identifiers

PMID35820563
PMCPMC13195624

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.