ArticleEuropean journal of medical research2022
Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study.
Article in European journal of medical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review).International journal of molecular medicine · 2026Review
- Prognostic significance of preoperative thyroid hormone sensitivity status for recurrence in papillary thyroid carcinoma.The oncologist · 2026Article
- Association between the systemic immune-inflammation index and risk of osteoarthritis: a cross-sectional NHANES 2013-2018 study.Clinical rheumatology · 2026Article
- Association between thyroid hormone sensitivity indices and renal function in community-dwelling euthyroid older adults: a cross-sectional study.Scientific reports · 2026Article
- Prematurity is associated with altered central thyroid hormone sensitivity.Frontiers in endocrinology · 2026Article
- Thyroid hormones and thyroid hormone sensitivity indices correlate with volumetric bone mineral density and vertebral fracture risk among the osteoporotic population in northern China.Frontiers in endocrinology · 2026Article
- Association between sensitivity to thyroid hormone indices and chronic kidney disease in US adults from NHANES 2007-2012.Renal failure · 2025Article
- Impaired sensitivity to thyroid hormones is associated with frailty in older patients with cardiometabolic disease.BMC geriatrics · 2025Article
- Relationship between RAR and the risk of osteoarthritis: a comprehensive analysis based on NHANES data (1999-2018).Journal of orthopaedics · 2025Article
- Correlation between thyroid sensitivity indices and bone metabolism in newly diagnosed middle aged and elderly patients with type 2 diabetes mellitus with normal thyroid function.BMC endocrine disorders · 2025Article
- Genetic evidence links hyperthyroidism to knee osteoarthritis.Hormones (Athens, Greece) · 2025Article
- Associations between estimated glucose disposal rate and osteoarthritis risk in US adults: a cross-sectional study.BMC musculoskeletal disorders · 2025Observational
- CRP-Albumin-Lymphocyte index (CALLYI) as a risk-predicting biomarker in association with osteoarthritis.Arthritis research & therapy · 2025Article
- Correlation between diabetic peripheral neuropathy and thyroid hormone sensitivity in elderly patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- Correlation between low testosterone levels and the risk of osteoarthritis: a cross-sectional analysis of NHANES data (2011-2016).BMC musculoskeletal disorders · 2025Article
- Elevated mitochondrial DNA copy number in euthyroid individuals with impaired peripheral sensitivity to thyroid hormones.Frontiers in endocrinology · 2025Article
- Association between dietary index for gut microbiota and osteoarthritis in the US population: the mediating role of systemic immune-inflammation index.Frontiers in nutrition · 2025Article
- Chronic thyrotoxic myopathy development is associated with thyroid hormone sensitivity index, predicted by lower-limb fatigue and the squat-up test.Scientific reports · 2024Article
- Causal factors for osteoarthritis risk revealed by mendelian randomization analysis.Aging clinical and experimental research · 2024Review
- Association of thyroid hormone with osteoarthritis: from mendelian randomization and RNA sequencing analysis.Journal of orthopaedic surgery and research · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThyroid hormones play an instrumental role in chondrogenic differentiation and matrix maturation. However, studies investigating the relationship between thyroid function and the risk of osteoarthritis (OA) remain scarce. This study was designed to investigate the correlation between thyroid status and OA from a novel perspective of sensitivity to thyroid hormones.
methodsThe study included 8478 people from the National Health and Nutrition Examination Survey (NHANES) 2007-2010. The sensitivity to thyroid hormone indices included Thyrotroph Thyroxine Resistance Index (TT4RI), Thyroid-stimulating hormone (TSHI), Thyroid Feedback Quantile-based Index (TFQI), and Free Triiodothyronine /Free thyroxine (FT3/FT4), which were calculated based on serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Considering the complex survey design and sample weights, we employed multivariate linear regression models and stratified analysis to evaluate the correlation between sensitivity to thyroid hormone indices and OA.
resultsStudy results indicated that participants with OA had elevated TT4RI, TSHI, and TFQI levels, and lower FT3/FT4 levels compared to those with non-arthritis. After adjusting for other covariates, FT3/FT4 was negatively associated with the risk of OA (OR = 1.162, 95%CI 1.048-1.478, P = 0.021); (OR = 1.261, 95%CI 1.078-1.623, P = 0.042). In subgroup analyses stratified by gender and BMI, participants with OA had higher TFQI levels compared to those without OA in both genders. (OR = 1.491, 95%CI 1.070-2.077, P = 0.018); (OR = 2.548, 95%CI 1.929-3.365, P < 0.001). The higher TFQI levels were consistently associated with the increased prevalence of OA in the BMI (< 18.5 kg/m
conclusionsThe levels of FT3/FT4, TSHI, TT4RI, and TFQI are strongly associated with the prevalence of OA, which illustrates the complex correlation between the thyroid system and chondrogenic differentiation. TFQI may be used as a helpful indicator to predict OA and provide novel ideas for the evaluation and treatment of OA.
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