Evidence map›Paper›PMID 35821821›Full record

ReviewFrontiers in aging2022

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.

Helen E Collins, Dingguo Zhang, John C Chatham

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Molecular Insights into Oral Manifestations in Sjögren's Disease.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Review
  5. Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Role of KDM2B epigenetic factor in regulating calcium signaling in prostate cancer cells.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
    Article
  11. Review
  12. Review
  13. The Dysfunction of CaInternational journal of molecular sciences · 2023
    Review
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Helen E CollinsDivision of Environmental Medicine, Department of Medicine, University of Louisville, Louisville, KY, United States.
Dingguo ZhangDivision of Molecular and Cellular Pathology, Department of PathologyUniversity of Alabama at Birmingham, Birmingham, AL, United States.
John C ChathamDivision of Molecular and Cellular Pathology, Department of PathologyUniversity of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USUniversity of Louisville · US

Funding

STIM1 and its role in regulating cardiac metabolismR01HL149354 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHATHAM, JOHN C, DARLEY-USMAR, VICTOR M · 2020 to 2023
$2.2M
NHLBI NIH HHS R01 HL149354
6 · The paper itself

Abstract

Tight spatiotemporal regulation of intracellular Ca

Indexed as

calciumcardiovascular diseasecell survivalneurodegenerationoraiSOCE channelsSTIM

Identifiers

PMID35821821
PMCPMC9261457
OpenAlexW4224266188

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.