Evidence map›Paper›PMID 35821991›Full record

ArticleFrontiers in aging2021

Altered Nutrient Uptake Causes Mitochondrial Dysfunction in Senescent CD8

Lauren A Callender, Elizabeth C Carroll, Conor Garrod-Ketchley, Johannes Schroth, Jonas Bystrom, Victoria Berryman, Melanie Pattrick, Desiree Campbell-Richards, Gillian A Hood, Graham A Hitman and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. The role of CD8Frontiers in immunology · 2026
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  7. Article
  8. Post-translational modifications in CD8Frontiers in immunology · 2026
    Review
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  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Lauren A CallenderWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Elizabeth C CarrollWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Conor Garrod-KetchleyWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Johannes SchrothWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Jonas BystromWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Victoria BerrymanBarts Health NHS Trust, London, United Kingdom.
Melanie PattrickBarts Health NHS Trust, London, United Kingdom.
Desiree Campbell-RichardsBarts Health NHS Trust, London, United Kingdom.
Gillian A HoodInstitute of Population Health Sciences, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Graham A HitmanBlizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Sarah FinerBarts Health NHS Trust, London, United Kingdom.
Sian M HensonWilliam Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Queen Mary University of London · GBBarts Health NHS Trust · GBWilliam Harvey Research Institute · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial health and cellular metabolism can heavily influence the onset of senescence in T cells. CD8

Indexed as

ageinginflammationmetabolismmitochondriasenescenceT celltype 2 diabetes

Identifiers

PMID35821991
PMCPMC9261431
OpenAlexW3193985244

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.