Evidence map›Paper›PMID 35831735›Full record

ArticleInflammopharmacology2022

Oxocrebanine from Stephania pierrei exerts macrophage anti-inflammatory effects by downregulating the NF-κB, MAPK, and PI3K/Akt signalling pathways.

Wanatsanan Chulrik, Chutima Jansakun, Waraluck Chaichompoo, Aman Tedasen, Pathumwadee Yotmanee, Apsorn Sattayakhom, Wilanee Chunglok, Apichart Suksamrarn, Warangkana Chunglok

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Wanatsanan ChulrikHealth Sciences (International Program), College of Graduate Studies, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0003-2804-4921
Chutima JansakunSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0002-7892-4436
Waraluck ChaichompooDepartment of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, 10330, Thailand.ORCID http://orcid.org/0000-0002-6359-5828
Aman TedasenSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0002-1350-1424
Pathumwadee YotmaneeDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-9129-5235
Apsorn SattayakhomSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand.ORCID http://orcid.org/0000-0003-1944-6881
Wilanee ChunglokDivision of Biological Science, Faculty of Science, Prince of Songkla University, Songkhla, 90110, Thailand.ORCID http://orcid.org/0000-0002-3552-060X
Apichart SuksamrarnDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok, 10240, Thailand.ORCID http://orcid.org/0000-0001-8919-3555
Warangkana ChunglokSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80160, Thailand. cwarang@wu.ac.th.ORCID http://orcid.org/0000-0002-8000-6052
Walailak University · THPrince of Songkla University · THRamkhamhaeng University · THChulalongkorn University · TH

Funding

a Walailak University Ph.D. Excellence Scholarship 04/2020the Center of Excellence for Innovation in Chemistry, Ministry of Higher Education, Science, Research, and Innovationthe new strategic research (P2P) project CGS-P2P-2564-054the Thailand Science Research and Innovation Fund WU-FF64102the Walailak University Graduate Research Fund CGS-RF-2021/05
6 · The paper itself

Abstract

Plant-derived medicinal compounds are increasingly being used to treat acute and chronic inflammatory diseases, which are generally caused by aberrant inflammatory responses. Stephania pierrei Diels, also known as Sabu-lueat in Thai, is a traditional medicinal plant that is used as a remedy for several inflammatory disorders. Since aporphine alkaloids isolated from S. pierrei tubers exhibit diverse pharmacological characteristics, we aimed to determine the anti-inflammatory effects of crude extracts and alkaloids isolated from S. pierrei tubers against lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Notably, the n-hexane extract strongly suppressed nitric oxide (NO) while exhibiting reduced cytotoxicity. Among the five alkaloids isolated from the n-hexane extract, the aporphine alkaloid oxocrebanine exerted considerable anti-inflammatory effects by inhibiting NO secretion. Oxocrebanine also significantly suppressed prostaglandin E

Indexed as

AporphinesStephaniaAnti-Inflammatory AgentsCyclooxygenase 2LipopolysaccharidesMacrophagesMolecular Docking SimulationNF-kappa BNitric OxideNitric Oxide Synthase Type IIPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAnti-Inflammatory AgentsAporphinesCyclooxygenase 2LipopolysaccharidesNF-kappa BNitric OxideNitric Oxide Synthase Type IIoxocrebaninePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAporphine alkaloidCyclooxygenaseInflammatory pathwayOxocrebanineStephania pierrei

Identifiers

PMID35831735
OpenAlexW4285395227

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.