ArticleClinical interventions in aging2022
Intrinsic Capacity Declines with Elevated Homocysteine in Community-Dwelling Chinese Older Adults.
Article in Clinical interventions in aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- The assessment and detection rate of intrinsic capacity deficits among older adults: a systematic review and meta-analysis.BMC geriatrics · 2024Pooled it
- Digital Divide or Compensatory Dividend? The Longitudinal Impact of Smart Health Monitoring on Intrinsic Capacity Trajectories.Healthcare (Basel, Switzerland) · 2026Article
- Exploring the multifaceted influencers on intrinsic capacity among community-dwelling older adults: a scoping review.BMC geriatrics · 2026Article
- Association between sleep duration and intrinsic capacity in older adults: evidence from a longitudinal cohort study and Bayesian network analyses.BMC geriatrics · 2026Article
- Impact of multimorbidity on health-related quality of life: the mediation role of intrinsic capacity - evidence from the WHO ICOPE pilot program in Lianyungang of China (2024).Archives of public health = Archives belges de sante publique · 2025Article
- Value shift in response to aging: a longitudinal study based on healthy aging.BMC geriatrics · 2025Article
- Association between multimorbidity and intrinsic capacity among older Chinese adults: evidence from the CHARLS 2011-2015.European geriatric medicine · 2025Article
- Article
- Determinants of intrinsic capacity among older adults in low- and middle-income countries: A scoping review.Belitung nursing journal · 2025Review
- Intrinsic capacity and its association with predictors among Chinese empty nest older adults in communities: a latent class analysis.BMC geriatrics · 2024Article
- A latent profile analysis of rest-activity behavior patterns among community-dwelling older adults and its relationship with intrinsic capacity.Scientific reports · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Intrinsic capacity (IC) reflects the overall health status of older adults and has great public health significance. But few studies described the related biomarkers for IC. The aim of this study was to investigate the association between homocysteine (Hcy) and IC in older adults. Participants and Methods: This cross-sectional study included 1927 community-dwelling Chinese older adults aged 60-98 years from May 2020 to December 2020. Data were collected through interviews, physical examinations, and laboratory tests. IC involved five domains of cognition, locomotion, sensory, vitality, and psychology evaluated by the Mini-cog scale, 4-m walk test, self-reported visual and hearing conditions, MNA-SF scale, and GDS-4 scale, respectively. The score of each domain dichotomized as 0 (normal) and 1 (impaired) was added together to an IC total score. Low IC was defined as a score of 3-5, and high IC as 0-2. Hcy was measured by a two-reagent enzymatic assay. A restricted cubic spline regression model was used to explore the non-linear relationship between Hcy and low IC. Results: Hcy was higher in the low IC group than in the high IC group. Restricted cubic spline analysis revealed a J-shaped nonlinear association between Hcy and low IC. The risk of IC decline was slowly decreased until 8.53 µmol/L of Hcy (OR=0.753, 95% CI=0.520-1.091, P=0.132), and increased with elevations of per 5 µmol/L Hcy afterwards (OR=1.176, 95% CI=1.059-1.327, P=0.005). Among the five domains of IC, Hcy had ORs of 1.116 (1.009-1.247) for cognition impairment, 1.167 (1.055-1.305) for vitality, and 1.160 (1.034-1.303) for psychology per 5 µmol/L increase in Hcy above the change point. Additional sensitivity analysis also demonstrated the nonlinear association between Hcy and low IC. Conclusion: Hcy had a J-shaped association with low IC. Higher Hcy (Hcy ≥8.53µmol/L) might provide clinical implications for early identifying the risk of low IC.
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