Evidence map›Paper›PMID 35832792›Full record

ReviewFrontiers in cell and developmental biology2022

Beth Levine's Legacy: From the Discovery of BECN1 to Therapies. A Mentees' Perspective.

Zhenyi An, Wei-Chung Chiang, Álvaro F Fernández, Luis H Franco, CongCong He, Shu-Yi Huang, Eunmyong Lee, Yang Liu, Salwa Sebti, Sanae Shoji-Kawata and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in cell and developmental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Zhenyi AnBroad Institute of MIT and Harvard, Cambridge, MA, United States.
Wei-Chung ChiangInstitute of Biochemistry and Molecular Biology, College of Life Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Álvaro F FernándezDepartamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Luis H FrancoDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
CongCong HeDepartment of Cell and Developmental Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Shu-Yi HuangDepartment of Medical Research, National Taiwan University Hospital, Taipei, Taiwan.
Eunmyong LeeInnoCure Therapeutics Inc., Gyeonggi-do, South Korea.
Yang LiuDepartment of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, United States.
Salwa SebtiDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Sanae Shoji-KawataDepartment of Pharmacy, Nishi Nara Central Hospital, Nara, Japan.
Shyam SirasanagandlaSt Jude Children's Research Hospital, Memphis, TN, United States.
Richard C WangDepartment of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Yongjie WeiCancer Research Institute, Guangzhou Medical University, Guangzhou, China.
Yuting ZhaoInstitute of Future Agriculture, Northwest A&F University, Yangling, China.
Silvia Vega-Rubin-de-CelisInstitute for Cell Biology (Cancer Research), Essen University Hospital, University of Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With great sadness, the scientific community received the news of the loss of Beth Levine on 15 June 2020. Dr. Levine was a pioneer in the autophagy field and work in her lab led not only to a better understanding of the molecular mechanisms regulating the pathway, but also its implications in multiple physiological and pathological conditions, including its role in development, host defense, tumorigenesis, aging or metabolism. This review does not aim to provide a comprehensive view of autophagy, but rather an outline of some of the discoveries made by the group of Beth Levine, from the perspective of some of her own mentees, hoping to honor her legacy in science.

Indexed as

agingBECN1Beth Levinecancerinfectious diseasesmacroautophagymetabolismselective autophagy

Identifiers

PMID35832792
PMCPMC9273008

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.