Evidence map›Paper›PMID 35834842›Full record

ReviewCell calcium2022

What structures did, and did not, reveal about the function of the epithelial Ca

Tibor Rohacs, Edwin C Fluck, José J De Jesús-Pérez, Vera Y Moiseenkova-Bell

Open access · greenAbstract readReview
In one paragraph

Review in Cell calcium, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. TRPV6-Mediated CaCancers · 2026
    Review
  3. Review
  4. Synergistic Effects of 25-Hydroxyvitamin DAnimals : an open access journal from MDPI · 2026
    Article
  5. Review
  6. Effects of 25-hydroxyvitamin DAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Article
  7. TRP channels in mammalian hearing loss.Frontiers in molecular neuroscience · 2025
    Review
  8. Article
  9. Structural mechanism of TRPV5 inhibition by econazole.Structure (London, England : 1993) · 2024
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tibor RohacsDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, New Jersey 07103, USA. Electronic address: rohacsti@njms.rutgers.edu.
Edwin C FluckDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
José J De Jesús-PérezDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Vera Y Moiseenkova-BellDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. Electronic address: vmb@pennmedicine.upenn.edu.
Translational Therapeutics (United States) · USRutgers, The State University of New Jersey · US

Funding

Regulation of the Intestinal Ca2+ Channels TRPV6R01GM093290 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI CARNEVALE, VINCENZO, ROHACS, TIBOR · 2011 to 2025
$4.9M
Structure and Function of TRPV channelsR35GM144120 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Vera Moiseenkova-Bell · 2022 to 2026
$4.2M
Structural Insights into TRPV Channel GatingR01GM103899 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2013 to 2021
$3.2M
Molecular mechanisms of TRPV5 gatingR01GM129357 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI MOISEENKOVA-BELL, VERA · 2018 to 2021
$1.7M
NIGMS NIH HHS R01 GM093290NIGMS NIH HHS R01 GM103899NIGMS NIH HHS R01 GM129357NIGMS NIH HHS R35 GM144120
6 · The paper itself

Abstract

Transient Receptor Potential Vanilloid 5 and 6 (TRPV5 and TRPV6) are Ca

Indexed as

CalciumTRPV Cation ChannelsAnimalsCalmodulinCryoelectron MicroscopyMammalsPhosphatidylinositolsCalciumCalmodulinPhosphatidylinositolsTRPV Cation ChannelsCryo electron microscopyStructure-based drug designTRPV5 channelTRPV6 channelX ray crystallography

Identifiers

PMID35834842
PMCPMC11500022
OpenAlexW4283787331

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.