Evidence map›Paper›PMID 35835166›Full record

ArticleEnvironmental research2022

Ambient air pollution during pregnancy and DNA methylation in umbilical cord blood, with potential mediation of associations with infant adiposity: The Healthy Start study.

Anne P Starling, Cheyret Wood, Cuining Liu, Katerina Kechris, Ivana V Yang, Chloe Friedman, Deborah S K Thomas, Jennifer L Peel, John L Adgate, Sheryl Magzamen and 3 more

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Cord blood DNA methylation as a potential mediator in the association between prenatal ambient air pollution and early infant allergic symptoms in a Shanghai birth cohort.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Prenatal black carbon exposure and DNA methylation in umbilical cord blood.International journal of hygiene and environmental health · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Anne P StarlingDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. Electronic address: anne.starling@unc.edu.
Cheyret WoodDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Cuining LiuDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Katerina KechrisDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Ivana V YangDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA; Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
Chloe FriedmanDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Deborah S K ThomasDepartment of Geography and Earth Sciences, University of North Carolina Charlotte, NC, USA.
Jennifer L PeelDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.
John L AdgateDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Sheryl MagzamenDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Department of Epidemiology, Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA.
Sheena E MarteniesDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA; Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
William B AllshouseDepartment of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Dana DabeleaDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA; Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Colorado School of Public Health · USColorado State University · USUniversity of Illinois Urbana-Champaign · USUniversity of North Carolina at Charlotte · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUH3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI Traci Allison Bekelman, Dana Dabelea · 2018 to 2026
$14.8M
Exploring the Fuel-Mediated Programming of Neonatal GrowthR01DK076648 · NIDDK · UNIVERSITY OF COLORADO DENVER/HSC DENVER · PI DABELEA, DANA · 2009 to 2018
$7.0M
The Early Life Exposome and Childhood Health - The Colorado Healthy Start 3 Cohort StudyUG3OD023248 · OD · UNIVERSITY OF COLORADO DENVER · PI BEKELMAN, TRACI ALLISON, DABELEA, DANA · 2016 to 2024
$5.9M
Endocrine disruptors, epigenetic programming and neonatal outcomesR01ES022934 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI ADGATE, JOHN L., DABELEA, DANA · 2014 to 2017
$2.3M
A mechanistic study of prenatal air pollution exposure and offspring obesity riskR00ES025817 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI STARLING, ANNE · 2017 to 2019
$713k
NIDDK NIH HHS R01 DK076648NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R00 ES025817NIEHS NIH HHS R01 ES022934NIH HHS UG3 OD023248NIH HHS UH3 OD023248
6 · The paper itself

Abstract

backgroundPrenatal exposure to ambient air pollution has been associated with adverse offspring health outcomes. Childhood health effects of prenatal exposures may be mediated through changes to DNA methylation detectable at birth.

methodsAmong 429 non-smoking women in a cohort study of mother-infant pairs in Colorado, USA, we estimated associations between prenatal exposure to ambient fine particulate matter (PM

resultsWe identified several DMRs for each pollutant and period of pregnancy. The greatest number of significant DMRs were associated with third trimester PM

conclusionsDifferentially methylated regions in cord blood were identified in association with maternal exposure to PM

Indexed as

Air PollutantsAir PollutionPrenatal Exposure Delayed EffectsAdiposityChildCohort StudiesDNA MethylationFemaleFetal BloodHumansInfantInfant, NewbornMaternal ExposureObesityParticulate MatterPregnancyAir PollutantsParticulate MatterAir pollutionCord bloodDNA methylationEpigeneticsOzoneParticulate matter

Identifiers

PMID35835166
PMCPMC10402394
OpenAlexW4285028994

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.