ArticleNature communications2022
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
8.2field-weighted citation impact, top 2% of its field
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Metabolomics biomarkers and related pathways in acute renal injury: a bibliometric investigation, meta-analysis, and systematic review.Frontiers in medicine · 2025Pooled it
- Plasma and Urinary Metabolomic Profiles Associated with the Salt Sensitivity of Blood Pressure in the Dietary Approaches to Stop Hypertension-Sodium Trial.The Journal of nutrition · 2026Trial
- Megalin: from structure to function.Nature reviews. Nephrology · 2026Review
- Article
- Nuclear Magnetic Resonance-Based Urinary Metabolic Profiling for Assessing Heat Stress-Related Incident Kidney Injury in Health-Care Workers.GeoHealth · 2026Article
- Plasma Metabolomics Reveals a Shared Metabolomic Profile in Experimental and Human Chronic Kidney Disease.Toxins · 2026Article
- Application of metabolomics in hypertension research: A bibliometric study and literature review.International journal of cardiology. Heart & vasculature · 2026Review
- Article
- MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats.iScience · 2026Article
- Blood metabolites mediate causal inference studies on the effect of gut microbiota on the risk of vascular calcification.Journal of advanced research · 2026Article
- Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease.Toxins · 2025Article
- Interactome Quantitation Reveals Non-Energetic Mitochondrial Roles in Cell Type Specialization in Murine Kidney.Molecular & cellular proteomics : MCP · 2025Article
- Proteolytic profiling of human plasma reveals an immunoactive complement C3 fragment.The EMBO journal · 2025Article
- Microbiota and kidney disease: the road ahead.Nature reviews. Nephrology · 2025Review
- Human plasma metabolomics reveals metabolic targets for intervention in salt-sensitive hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Longitudinal Multi-Organ Transcriptomic Atlas of Salt-Induced Hypertension.bioRxiv : the preprint server for biology · 2025Article
- Wheat-Based Protein Slows Disease Progression in Pkd1 Knockout Mice.Function (Oxford, England) · 2025Article
- Biology of the proximal tubule in body homeostasis and kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Mechanistic Insights Into Redox Damage of the Podocyte in Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Review
- Association of tricarboxylic acid cycle related-metabolites with hypertension in older adults: a community-based cross-sectional study.Journal of human hypertension · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 7 institutions in 4 countries.
Markus M Rinschen *Scripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA. rinschen@biomed.au.dk.ORCID 0000-0002-9252-1342
Oleg Palygin *Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.ORCID 0000-0002-3680-5527
Ashraf El-MeanawyDivision of Nephrology, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0002-3114-5312
Xavier Domingo-AlmenaraScripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA.ORCID 0000-0002-0133-6863
Amelia PalermoScripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA.
Lashodya V DissanayakeDepartment of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, 33602, USA.ORCID 0000-0002-2329-0931
Daria GolosovaDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.ORCID 0000-0002-9663-9639
Michael A SchafrothDepartment of Chemistry, Scripps Research, La Jolla, CA, 92037, USA.ORCID 0000-0002-5864-6766
Carlos GuijasScripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA.
Fatih DemirDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-5744-0205
Johannes JaegersDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID 0000-0002-9815-2402
Megan L GliozziRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Jingchuan XueScripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA.
Martin HoehneCenter for Molecular Medicine Cologne, Cologne, Germany.ORCID 0000-0001-8698-5389
Thomas BenzingCenter for Molecular Medicine Cologne, Cologne, Germany.ORCID 0000-0003-0512-1066
Bernard P KokDepartment of Molecular Medicine, Scripps Research, La Jolla, CA, 92037, USA.
Enrique SaezDepartment of Molecular Medicine, Scripps Research, La Jolla, CA, 92037, USA.ORCID 0000-0001-5718-5542
Markus BleichInstitute of Physiology, University Kiel, Kiel, Germany.ORCID 0000-0002-1745-2295
Nina HimmerkusInstitute of Physiology, University Kiel, Kiel, Germany.
Ora A WeiszRenal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Benjamin F CravattDepartment of Chemistry, Scripps Research, La Jolla, CA, 92037, USA.ORCID 0000-0001-5330-3492
Marcus KrügerCenter for Molecular Medicine Cologne, Cologne, Germany.ORCID 0000-0002-5846-6941
H Paul BentonScripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA.ORCID 0000-0002-4248-2269
Gary Siuzdak *Scripps Center for Metabolomics, Scripps Research, La Jolla, CA, 92037, USA. siuzdak@scripps.edu.ORCID 0000-0002-4749-0014
Alexander Staruschenko *Department of Molecular Pharmacology and Physiology, University of South Florida, Tampa, FL, 33602, USA. staruschenko@usf.edu.ORCID 0000-0002-5190-8356
Scripps Institution of Oceanography · USMedical College of Wisconsin · USCologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases · DEAarhus University · DKScripps Research Institute · USUniversity of Pittsburgh · USMedical University of South Carolina · US
Funding
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1MChemical Proteomic Platforms for Radically Expanding Cancer DruggabilityR35CA231991 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI BENJAMIN F CRAVATT · 2018 to 2026
$9.5MChemoproteomic Identification and Therapeutic Validation of Proteins of Metabolic SignificanceRC2DK114785 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI CRAVATT, BENJAMIN F, SAEZ, ENRIQUE · 2017 to 2021
$8.2MMetabolomics Technologies to Advance Biomedical ResearchR35GM130385 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GARY E SIUZDAK · 2019 to 2026
$3.9MRenal ion channels in the control of blood pressureR35HL135749 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI STARUSCHENKO, ALEXANDER · 2017 to 2023
$3.6MRole of basolateral K channels in renal salt handling and BP controlR01DK126720 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI PALYGIN, OLEG · 2021 to 2024
$1.5MTransport and metabolism in the kidneyI01BX004024 · VA · JAMES A. HALEY VA MEDICAL CENTER · PI STARUSCHENKO, ALEXANDER · 2019 to 2025
–BLRD VA I01 BX004024NCATS NIH HHS UL1 TR001450NCI NIH HHS R35 CA231991NHLBI NIH HHS R35 HL135749NIDDK NIH HHS R01 DK126720NIDDK NIH HHS RC2 DK114785NIGMS NIH HHS R35 GM130385
Abstract
Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine's metabolic fate in vivo. Dietary
Indexed as
HypertensionKidneyLysineAlbuminsAnimalsCarbonDisease Models, AnimalMalonyl Coenzyme ARatsAlbuminsCarbonLysineMalonyl Coenzyme A
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What Socratic holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.