Evidence mapPaperPMID 35836697Full record

ArticleJournal of nutritional science2022

Retinoic acid promotes tissue vitamin A status and modulates adipose tissue metabolism of neonatal rats exposed to maternal high-fat diet-induced obesity.

Libo Tan, Yanqi Zhang, Hui Wang, Heleena Haberer

Open access · goldAbstract read
In one paragraph

Article in Journal of nutritional science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Libo TanDepartment of Human Nutrition, University of Alabama, 407 Russell Hall, 504 University Blvd, Tuscaloosa, AL 35487, USA.
Yanqi ZhangDepartment of Human Nutrition, University of Alabama, 407 Russell Hall, 504 University Blvd, Tuscaloosa, AL 35487, USA.
Hui WangDepartment of Human Nutrition, University of Alabama, 407 Russell Hall, 504 University Blvd, Tuscaloosa, AL 35487, USA.
Heleena HabererDepartment of Biological Sciences, University of Alabama, Tuscaloosa, AL 35487, USA.
University of Alabama · US

Funding

Vitamin A Supplementation and Retinol Metabolism in the Neonatal PeriodR01HD066982 · NICHD · PENNSYLVANIA STATE UNIVERSITY, THE · PI ROSS, A. CATHARINE · 2010 to 2019
$2.9M
NICHD NIH HHS R01 HD066982
6 · The paper itself

Abstract

Maternal obesity may compromise the micronutrient status of the offspring. Vitamin A (VA) is an essential micronutrient during neonatal development. Its active metabolite, retinoic acid (RA), is a key regulator of VA homeostasis, which also regulates adipose tissue (AT) development in obese adults. However, its role on VA status and AT metabolism in neonates was unknown and it was determined in the present study. Pregnant Sprague-Dawley rats were randomised to a normal fat diet (NFD) or a high fat diet (HFD). From postnatal day 5 (P5) to P20, half of the HFD pups received oral RA every 3 d (HFDRA group). NFD pups and the remaining HFD pups (HFD group) received placebo. Six hours after dosing on P8, P14 and P20,

Indexed as

Diet, High-FatPregnancy in ObesityAdipose TissueAnimalsAnimals, NewbornFemaleHumansMicronutrientsObesityPregnancyRatsRats, Sprague-DawleyTretinoinVitamin AWeight GainMicronutrientsTretinoinVitamin AAdipose tissueBAT, brown adipose tissueBW, body weightHFD, high fat dietLRAT, lecithin:retinol acyltransferaseMaternal obesityNeonatal lungNeonatal obesityNeonateNFD, normal fat dietP, postnatalRA, retinoic acidRAR, retinoic acid receptorRetinoic acidRXR, retinoid X receptorUCP, uncoupling proteinUPLC, ultra-high-performance liquid chromatographyVA, vitamin AVitamin AWAT, white adipose tissue

Identifiers

PMID35836697
PMCPMC9274391
OpenAlexW4285238782

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.