Evidence map›Paper›PMID 35840310›Full record

ReviewESC heart failure2022

Exercise and nutritional interventions on sarcopenia and frailty in heart failure: a narrative review of systematic reviews and meta-analyses.

Konstantinos Prokopidis, Masoud Isanejad, Asangaedem Akpan, Maria Stefil, Behnam Tajik, Panagiotis Giannos, Massimo Venturelli, Rajiv Sankaranarayanan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Article
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  5. Article
  6. Observational
  7. Review
  8. Article
  9. Article
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  12. Article
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  15. Article
  16. The Dual Burden of Frailty and Heart Failure.International journal of heart failure · 2024
    Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Konstantinos ProkopidisDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.ORCID 0000-0002-6264-9388
Masoud IsanejadDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.
Asangaedem AkpanDepartment of Musculoskeletal Biology, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK.ORCID 0000-0002-1764-8669
Maria StefilLiverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.
Behnam TajikKuopio Musculoskeletal Research Unit, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-8453-3909
Panagiotis GiannosDepartment of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, UK.ORCID 0000-0003-1037-1983
Massimo VenturelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID 0000-0002-2469-8787
Rajiv SankaranarayananLiverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK.ORCID 0000-0003-2355-2011
University of Liverpool · GBUniversity of Verona · ITImperial College London · GBUniversity of Eastern Finland · FI

Funding

Medical Research Council MR/P020941/1
6 · The paper itself

Abstract

The purpose of this review is to describe the present evidence for exercise and nutritional interventions as potential contributors in the treatment of sarcopenia and frailty (i.e. muscle mass and physical function decline) and the risk of cardiorenal metabolic comorbidity in people with heart failure (HF). Evidence primarily from cross-sectional studies suggests that the prevalence of sarcopenia in people with HF is 37% for men and 33% for women, which contributes to cardiac cachexia, frailty, lower quality of life, and increased mortality rate. We explored the impact of resistance and aerobic exercise, and nutrition on measures of sarcopenia and frailty, and quality of life following the assessment of 35 systematic reviews and meta-analyses. The majority of clinical trials have focused on resistance, aerobic, and concurrent exercise to counteract the progressive loss of muscle mass and strength in people with HF, while promising effects have also been shown via utilization of vitamin D and iron supplementation by reducing tumour necrosis factor-alpha (TNF-a), c-reactive protein (CRP), and interleukin-6 (IL-6) levels. Experimental studies combining the concomitant effect of exercise and nutrition on measures of sarcopenia and frailty in people with HF are scarce. There is a pressing need for further research and well-designed clinical trials incorporating the anabolic and anti-catabolic effects of concurrent exercise and nutrition strategies in people with HF.

Indexed as

FrailtyHeart FailureSarcopeniaCross-Sectional StudiesExerciseFemaleHumansMaleQuality of LifeSystematic Reviews as TopicExerciseFrailtyHeart failureNutritionQuality of lifeSarcopenia

Identifiers

PMID35840310
PMCPMC9715780
OpenAlexW4285588910

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.