Evidence map›Paper›PMID 35844258›Full record

ArticleComputational toxicology (Amsterdam, Netherlands)2022

Current status and future directions for a neurotoxicity hazard assessment framework that integrates

Kevin M Crofton, Arianna Bassan, Mamta Behl, Yaroslav G Chushak, Ellen Fritsche, Jeffery M Gearhart, Mary Sue Marty, Moiz Mumtaz, Manuela Pavan, Patricia Ruiz and 10 more

Open access · greenAbstract read
In one paragraph

Article in Computational toxicology (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. A cryopreserved andNAM journal · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Principles and Procedures for Assessment of Acute Toxicity IncorporatingComputational toxicology (Amsterdam, Netherlands) · 2022
    Article
  15. Article
  16. Computational toxicology (Amsterdam, Netherlands) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 10 institutions in 4 countries.

Kevin M CroftonR3Fellows LLC, Durham, NC, 27705, USA.
Arianna BassanInnovatune srl, Via Giulio Zanon 130/D, 35129 Padova, Italy.
Mamta BehlDivision of the National Toxicology Program, National Institutes of Environmental Health Sciences, Durham, NC 27709, USA.
Yaroslav G ChushakHenry M Jackson Foundation for the Advancement of Military Medicine, Wright-Patterson AFB, OH 45433, USA.
Ellen FritscheIUF - Leibniz Research Institute for Environmental Medicine & Medical Faculty Heinrich-Heine-University, Düsseldorf, Germany.
Jeffery M GearhartHenry M Jackson Foundation for the Advancement of Military Medicine, Wright-Patterson AFB, OH 45433, USA.
Mary Sue MartyThe Dow Chemical Company, Midland, MI 48667, USA.
Moiz MumtazAgency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA.
Manuela PavanInnovatune srl, Via Giulio Zanon 130/D, 35129 Padova, Italy.
Patricia RuizAgency for Toxic Substances and Disease Registry, US Department of Health and Human Services, Atlanta, GA, USA.
Magdalini SachanaEnvironment Health and Safety Division, Environment Directorate, Organisation for Economic Co-Operation and Development (OECD), 75775 Paris Cedex 16, France.
Rajamani SelvamOffice of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.
Timothy J ShaferBiomolecular and Computational Toxicology Division, Center for Computational Toxicology and Exposure, US EPA, Research Triangle Park, NC, USA.
Lidiya StavitskayaOffice of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research (CDER), U.S. Food and Drug Administration (FDA), Silver Spring, MD 20993, USA.
David T SzaboPPG Industries, Pittsburgh, PA 15146, USA.
Steven T SzaboSzabo Consulting LLC, Durham, NC 27703, USA.
Raymond R TiceRTice Consulting, Hillsborough, NC 27278, USA.
Dan WilsonThe Dow Chemical Company, Midland, MI 48667, USA.
David WoolleyForthTox Limited, Linlithgow, UK.
Glenn J MyattInstem, Columbus, OH 43215, USA.
Agency for Toxic Substances and Disease Registry · USCenter for Drug Evaluation and Research · USDow Chemical (United States) · USHenry M. Jackson Foundation · USInnova (Italy) · ITEnvironmental Protection Agency · USHeinrich Heine University Düsseldorf · DENational Institute of Environmental Health Sciences · USOrganisation de Coopération et de Développement Economiques · FRPPG Industries (United States) · US

Funding

Rapid response toxicology prediction platformR44ES026909 · NIEHS · LEADSCOPE, INC. · PI MYATT, GLENN JOHN · 2018 to 2019
$1000k
NIEHS NIH HHS R44 ES026909
6 · The paper itself

Abstract

Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to assess developmental (DNT) and adult (NT) neurotoxicity induced by xenobiotics is critically needed. The use of such alternative methods including

Indexed as

Computational toxicologyDevelopmental neurotoxicityExpert systemHazard identificationIn silicoIn silico toxicology protocolsNeurotoxicityProfilersQSARRead-acrossRisk assessment

Identifiers

PMID35844258
PMCPMC9281386
OpenAlexW4280627812

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.