ArticleThe Journal of clinical investigation1987
Characterization of an abnormal species of apolipoprotein B, apolipoprotein B-37, associated with familial hypobetalipoproteinemia.
Article in The Journal of clinical investigation, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 115 citations in OpenAlex.
- Review
- Article
- The gut microbiota modulates host energy and lipid metabolism in mice.Journal of lipid research · 2010Article
- Kringle-containing fragments of apolipoprotein(a) circulate in human plasma and are excreted into the urine.The Journal of clinical investigation · 1996Article
- A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.The Journal of clinical investigation · 1995Article
- Transgenic mice expressing high plasma concentrations of human apolipoprotein B100 and lipoprotein(a).The Journal of clinical investigation · 1993Article
- Targeted modification of the apolipoprotein B gene results in hypobetalipoproteinemia and developmental abnormalities in mice.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Reading-frame restoration with an apolipoprotein B gene frameshift mutation.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Modification of the apolipoprotein B gene in HepG2 cells by gene targeting.The Journal of clinical investigation · 1992Article
- Transcriptional regulation of the apolipoprotein B100 gene: purification and characterization of trans-acting factor BRF-2.Molecular and cellular biology · 1992Article
- Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.The Journal of clinical investigation · 1991Article
- A truncated species of apolipoprotein B (B67) in a kindred with familial hypobetalipoproteinemia.The Journal of clinical investigation · 1991Article
- Human small-intestinal apolipoprotein B-48 oligosaccharide chains.The Biochemical journal · 1991Article
- Familial hypobetalipoproteinemia caused by a mutation in the apolipoprotein B gene that results in a truncated species of apolipoprotein B (B-31). A unique mutation that helps to define the portion of the apolipoprotein B molecule required for the formation of buoyant, triglyceride-rich lipoproteins.The Journal of clinical investigation · 1990Article
- Biosynthetic precursor (214 kDa) of apolipoprotein B-48 is not secreted by Caco-2 cells and normal human intestine.The Biochemical journal · 1989Article
- Genetic basis of lipoprotein disorders.The Journal of clinical investigation · 1989Review
- Low density lipoprotein undergoes oxidative modification in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1989Article
- Genetic evidence from two families that the apolipoprotein B gene is not involved in abetalipoproteinemia.The Journal of clinical investigation · 1988Article
- Truncated variants of apolipoprotein B cause hypobetalipoproteinaemia.Nucleic acids research · 1988Article
- Inference of a molecular defect of apolipoprotein B in hypobetalipoproteinemia by linkage analysis in a large kindred.The Journal of clinical investigation · 1988Article
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4 authors.
Funding
Abstract
Steinberg and colleagues have previously described a unique kindred with normotriglyceridemic hypobetalipoproteinemia (1979. J. Clin. Invest. 64:292-301). In a reexamination of this kindred, we found an abnormal apolipoprotein (apo) B species, apo B-37 (203,000 mol wt), in the plasma lipoproteins of multiple members of the kindred. In affected individuals apo B-37 was found in very low density lipoproteins, along with the normal apo B species, apo B-100 and apo B-48. High density lipoproteins (HDL) also contained apo B-37, but no other apo B species. The first 13 amino-terminal amino acids of apo B-37 were identical to those of normal apo B-100. We utilized a panel of 18 different apo B-specific monoclonal antibodies and polyclonal antisera specific for apo B-37 and the thrombin cleavage products of apo B-100 to map apo B-37 in relation to apo B-100, apo B-48, and the thrombin cleavage products of apo B-100. The results of those immunochemical studies indicated that apo B-37 contains only amino-terminal domains of apo B-100. In affected individuals, the majority of apo B-37 in plasma was contained in the HDL density fraction. Within that fraction apo B-37 was found on discrete lipoprotein particles, termed Lp-B37, that had properties distinct from normal HDL particles containing apo A-I. This report documents for the first time the existence of an abnormal apo B species in humans. Further study of apo B-37 and lipoprotein particles containing apo B-37 should lead to an improved understanding of apo B structure and function.
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