Evidence mapPaperPMID 35844722Full record

ArticleEJHaem2021

The effect of underlying inflammation on iron metabolism, cardiovascular risk and renal function in patients with type 2 diabetes.

Fransina Ndevahoma, Bongani B Nkambule, Phiwayinkosi V Dludla, Munyaradzi Mukesi, Kandiwapa N Natanael, Tawanda M Nyambuya

Open access · diamondAbstract read
In one paragraph

Article in EJHaem, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Fransina NdevahomaDepartment of Health Sciences Faculty of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia.
Bongani B NkambuleSchool of Laboratory Medicine and Medical Sciences College of Health Sciences University of KwaZulu-Natal Durban South Africa.
Phiwayinkosi V DludlaBiomedical Research and Innovation Platform South African Medical Research Council Cape Town South Africa.
Munyaradzi MukesiDepartment of Health Sciences Faculty of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia.
Kandiwapa N NatanaelDivision of Primary Healthcare at Katutura Community Health Centre Ministry of Health and Social Services Windhoek Namibia.
Tawanda M NyambuyaDepartment of Health Sciences Faculty of Health and Applied Sciences Namibia University of Science and Technology Windhoek Namibia.
Namibia University of Science and Technology · NAMinistry of Health and Social Services · NASouth African Medical Research Council · ZAUniversity of KwaZulu-Natal · ZA

Funding

FIC NIH HHS D43 TW010131
6 · The paper itself

Abstract

Aim: To investigate the impact of inflammation on iron metabolism, cardiovascular risk and renal function in type 2 diabetes (T2D). Methods: A total of 50 patients with T2D were included in this study. The patients were stratified into two groups based on their levels of C-reactive protein (CRP), namely normal and high levels ( Results: Fasting plasma glucose levels were elevated in patients with high CRP when compared to those with normal levels ( Conclusion: Underlying inflammation in T2D is associated with increased incidence of hypertension and reduced levels of serum iron, MCV and renal function. Although there was no apparent clinical anaemia or renal dysfunction in these patients, mitigating inflammation may be effective in circumventing the ultimate development of iron deficiency anaemia and chronic kidney disease in T2D.

Indexed as

anaemiacardiovascular riskdiabetic nephropathyinflammationtype 2 diabetes

Identifiers

PMID35844722
PMCPMC9176139
OpenAlexW3178661737

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.