Evidence map›Paper›PMID 35846992›Full record

ReviewFrontiers in pharmacology2022

Herb and Spices in Colorectal Cancer Prevention and Treatment: A Narrative Review.

Md Sanower Hossain, Md Abdul Kader, Khang Wen Goh, Maidul Islam, Md Sharif Khan, Md Harun-Ar Rashid, Der Jiun Ooi, Henrique Douglas Melo Coutinho, Yaser Mohammed Al-Worafi, Said Moshawih and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
59.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 343 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 5 countries.

Md Sanower HossainDepartment of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan, Malaysia.
Md Abdul KaderDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Khang Wen GohFaculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.
Maidul IslamDigital Medical Systems Ltd., Dhaka, Bangladesh.
Md Sharif KhanDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Md Harun-Ar RashidDepartment of Nutrition and Food Engineering, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.
Der Jiun OoiDepartment of Oral Biology & Biomedical Sciences, Faculty of Dentistry, MAHSA University, Jenjarom, Malaysia.
Henrique Douglas Melo CoutinhoDepartamento de Química Biológica, Laboratório de Microbiologia E Biologia Molecular-LMBM, Universidade Regional Do Cariri, URCA, Crato, Brazil.
Yaser Mohammed Al-WorafiCollege of Medical Sciences, Azal University for Human Development, Amran, Yemen.
Said MoshawihPAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei.
Ya Chee LimPAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei.
K M Kaderi KibriaDepartment of Biotechnology and Genetic Engineering, Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Long Chiau MingPAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Bandar Seri Begawan, Brunei.
Mawlana Bhashani Science and Technology University · BDUniversiti Brunei Darussalam · BNDaffodil International University · BDInternational Islamic University Malaysia · MYINTI International University · MYMahsa University · MYUniversidade Regional do Cariri · BRUniversity of Science and Technology of Fujairah

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the second most deadly cancer worldwide. CRC management is challenging due to late detection, high recurrence rate, and multi-drug resistance. Herbs and spices used in cooking, practised for generations, have been shown to contain CRC protective effect or even be useful as an anti-CRC adjuvant therapy when used in high doses. Herbs and spices contain many bioactive compounds and possess many beneficial health effects. The chemopreventive properties of these herbs and spices are mainly mediated by the BCL-2, K-ras, and MMP pathways, caspase activation, the extrinsic apoptotic pathway, and the regulation of ER-stress-induced apoptosis. As a safer natural alternative, these herbs and spices could be good candidates for chemopreventive or chemotherapeutic agents for CRC management because of their antiproliferative action on colorectal carcinoma cells and inhibitory activity on angiogenesis. Therefore, in this narrative review, six different spices and herbs: ginger (

Indexed as

biomoleculescolon cancerdrug resistancefunctional foodsmanagementnutraceuticalsprevalence

Identifiers

PMID35846992
PMCPMC9280164
OpenAlexW4283721582

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.