ReviewActa pharmaceutica Sinica. B2022
The regulatory and modulatory roles of TRP family channels in malignant tumors and relevant therapeutic strategies.
Open access · diamondAbstract readReview
In one paragraph
Review in Acta pharmaceutica Sinica. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
10.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 131 citations in OpenAlex.
- Cannabidiol effects in stem cells: A systematic review.BioFactors (Oxford, England)Pooled it
- Matrix nanoalignment programs macrophage vesicular immunity through TRPV2 mechanogating.Bioactive materials · 2027Article
- Transient receptor potential channels inChannels (Austin, Tex.) · 2026Review
- Biofabrication and artificial intelligence strategies for investigating solid- and fluid-pressure mechanobiology in pancreatic ductal adenocarcinoma.Cancer metastasis reviews · 2026Review
- Advances in applications of siRNA in cancer therapy: challenges and opportunities.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Hydrogen peroxide self-supplied nanozyme system for synergistic prostate cancer therapy via ferroptosis/pyroptosis and CaJournal of nanobiotechnology · 2026Article
- Integrative analysis of single-cell and transcriptomic data with RT-qPCR validation explores TRPM4-associated gene signatures in osteoarthritis synovium.Scientific reports · 2026Article
- Three-dimensional interactive network: Mitochondrial-metabolic-calcium homeostasis driving Alzheimer's disease.Genes & diseases · 2026Review
- DAMP signaling networks: from receptors to diverse pathophysiological functions.Journal of advanced research · 2026Review
- Multiscale analysis and optimal glioma therapeutic candidate discovery using the CANDO platform.Journal of cheminformatics · 2026Article
- Beyond Epilepsy Control: Repurposing Antiepileptic Drugs in Central Nervous System Tumor Therapy.Cells · 2026Review
- Article
- Carboxylated prodrug of capsaicin with enhanced peripheral nerve permeation mediated by monocarboxylate transporters for long-lasting local anesthesia.Acta pharmaceutica Sinica. B · 2026Article
- The Mechanism of Oxidative Stress in Pulmonary Fibrosis and Research Progress.Antioxidants (Basel, Switzerland) · 2026Review
- Transient receptor potential canonical 3 is required for HPV-induced malignant transformation of cervical epithelial cells.Communications biology · 2026Article
- CcTRP1, a Putative TRP Channel in Cordyceps cicadae, Regulates Hyphal Growth, Stress Responses, and Bioactive Metabolite Biosynthesis.Current microbiology · 2026Article
- Intestinal stem cells as innate immune sentinels: coupling environmental sensing to epithelial adaptation.Frontiers in immunology · 2026Review
- From neuro-immune command circuits to microbiota-mediated regulation in the gastrointestinal tumor microenvironment.Frontiers in immunology · 2026Review
- Calcium imbalance drives organelle network collapse and immune remodeling: novel pathogenic mechanisms in MASLD progression.Frontiers in immunology · 2026Review
- NCX1 interacts with TRPA1 to promote cell proliferation and tumor growth of colon cancer via disruption of calcium homeostasis.Journal of advanced research · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Tiecheng ZhongZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Wenxin ZhangZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Hongjie GuoZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Xiaohui PanZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Xi ChenZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Qiaojun HeZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Bo YangZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Ling DingZhejiang Province Key Laboratory of Anti-Cancer Drug Research, Institute of Pharmacology and Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Zhejiang University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient receptor potential (TRP) channels are one primary type of calcium (Ca
Indexed as
4α-PDD, 4α-phorbol-12,13-didecanoateABCB, ATP-binding cassette B1AKT, protein kinase BALA, alpha lipoic acidAMPK, AMP-activated protein kinaseAPB, aminoethoxydiphenyl borateATP, adenosine triphosphateCancer progressionCaR, calcium-sensing receptorCaSR, calcium sensing receptorCBD, cannabidiolCRAC, Ca2+ release-activated Ca2+ channelDAG, diacylglycerolDBTRG, Denver Brain Tumor Research GroupECFC, endothelial colony-forming cellsECM, enhanced extracellular matrixEGF, epidermal growth factorEMT, epithelial–mesenchymal transitionER, endoplasmic reticulumERK, extracellular signal-regulated kinaseETS, erythroblastosis virus E26 oncogene homologFAK, focal adhesion kinaseGADD, growth arrest and DNA damage-inducible geneGC, gastric cancerGPCR, G-protein coupled receptorGSC, glioma stem-like cellsGSK, glycogen synthase kinaseHCC, hepatocellular carcinomaHIF, hypoxia-induced factorHSC, hematopoietic stem cellsIntracellular mechanismIP3R, inositol triphosphate receptorKO, knockoutLOX, lipoxygenaseLPS, lipopolysaccharideLRP, lipoprotein receptor-related proteinMAPK, mitogen-activated protein kinaseMLKL, mixed lineage kinase domain-like proteinMMP, matrix metalloproteinasesmTOR, mammalian target of rapamycinNEDD4, neural precursor cell expressed, developmentally down-regulated 4NFAT, nuclear factor of activated T-cellsNLRP3, NLR family pyrin domain containing 3NO, nitro oxideNrf2, nuclear factor erythroid 2-related factor 2NSCLC, non-small cell lung cancerPCa, prostate cancerPDAC, pancreatic ductal adenocarcinomapFRG/RTN, parafacial respiratory group/retrotrapezoid nucleusP-gp, P-glycoproteinPHD, prolyl hydroxylasesPI3K, phosphoinositide 3-kinasePKC, protein kinase CPKD, polycystic kidney diseasePLC, phospholipase CProgrammed cancer cell deathRNS/ROS, reactive nitrogen species/reactive oxygen speciesRTX, resiniferatoxinSMAD, Caenorhabditis elegans protein (Sma) and mothers against decapentaplegic (Mad)SOCE, store operated calcium entrySOR, soricimedSTIM1, stromal interaction molecules 1Targeted tumor therapyTEC, tumor endothelial cellsTGF, transforming growth factor-βTNF-α, tumor necrosis factor-αTRPA/C/M/ML/N/P/V, transient receptor potential ankyrin/canonical/melastatin/mucolipon/NOMPC/polycystin/vanilloidTRP channelsTumor-associated immunocytesTumor microenvironmentUPR, unfolded protein responseVEGF, vascular endothelial growth factorVIP, vasoactive intestinal peptideVPAC, vasoactive intestinal peptide receptor subtype
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.