ArticleFrontiers in aging neuroscience2022
Effects of a 5-Year Exercise Intervention on White Matter Microstructural Organization in Older Adults. A Generation 100 Substudy.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of aerobic exercise and cardiorespiratory fitness on white matter free water fraction in older adults: a 1-year randomized controlled trial.GeroScience · 2026Trial
- Growth of White Matter Signal Aberrations and Cortical Changes in Men and Women: A 9-Year Multiple-Time-Point Longitudinal MRI Study in Older Adults.Human brain mapping · 2026Article
- Correlations between white matter hyperintensities, magnetic resonance imaging findings, and cognition in the oldest old: a multimodal cross-sectional study.GeroScience · 2026Article
- The active ingredients: physical activity features linked to healthy brain aging.Alzheimer's research & therapy · 2026Article
- Longitudinal sex differences in cerebrovascular ageing in older adults: results from the brain in motion study.The Journal of physiology · 2026Article
- Insulin resistance in cerebral small vessel disease: a mini review.Frontiers in neuroscience · 2026Review
- Non-invasive visual theta entrainment modulates myelin-related and functional outcomes in an LPC-induced demyelination model.PloS one · 2026Article
- Mechanisms of interventions targeting modifiable factors for dementia risk reduction.Molecular neurodegeneration · 2025Review
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Article
- The effects of a six-month exercise intervention on white matter microstructure in older adults at risk for diabetes.Cerebral circulation - cognition and behavior · 2024Article
- Microstructural organization of the corpus callosum in young endurance athletes: A global tractography study.Frontiers in neuroscience · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aerobic fitness and exercise could preserve white matter (WM) integrity in older adults. This study investigated the effect on WM microstructural organization of 5 years of exercise intervention with either supervised moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), or following the national physical activity guidelines. A total of 105 participants (70-77 years at baseline), participating in the randomized controlled trial Generation 100 Study, volunteered to take part in this longitudinal 3T magnetic resonance imaging (MRI) study. The HIIT group (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.