Evidence map›Paper›PMID 35852149›Full record

ArticleBioscience reports2022

Differential expression profile of mRNAs, lncRNAs, and circRNAs reveals potential molecular mechanism in breast cancer.

Yuan Li, Chiseng Lei, Yude Xie, Jie Zhang, Ningxia Wang, Weili He, Shaohua Qu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioscience reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yuan Li *Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.ORCID 0000-0001-9928-5584
Chiseng Lei *Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Yude Xie *Department of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Jie ZhangDepartment of Reproductive Medical Center, Guangdong Women and Children Hospital, Guangzhou, China.
Ningxia WangDepartment of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Weili HeDepartment of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
Shaohua QuDepartment of Breast Surgery, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China.
First Affiliated Hospital of Jinan University · CNGuangdong Province Women and Children Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, breast cancer attracts more and more attention because of its high incidence. To explore the molecular functions and mechanisms, we performed RNA sequencing on the tumor tissues and their paired normal tissues from three breast cancer patients. By differential expression analysis, we found 3764 differentially expressed (DE) mRNAs, 5416 DE lncRNAs, and 148 DE circRNAs. Enrichment analysis suggested that the DE lncRNAs and DE circRNAs were enriched in mitochondria and nucleus, which indicated that they may participate in the vital metabolism directly or indirectly, such as fatty acid metabolism. Subsequently, the protein-protein interaction (PPI) network was constructed and we got 8 key proteins, of which the matrix metalloproteinase-9 (MMP9; degree 5) draws our attention. Based on the 38 up-regulated circRNAs and 14 down-regulated circRNAs, we constructed competing endogenous RNA (ceRNA) networks, from which the has-miR-6794-5p has been identified to enriched in the up-regulated network and correlated with the circNFIX directly. At this point, we presented that the circNFIX and MMP9 may play a significant role by regulating fatty acid metabolism in breast cancer.

Indexed as

Breast NeoplasmsMicroRNAsRNA, Long NoncodingFatty AcidsFemaleGene Regulatory NetworksHumansMatrix Metalloproteinase 9RNA, CircularRNA, MessengerFatty AcidsMatrix Metalloproteinase 9MicroRNAsRNA, CircularRNA, Long NoncodingRNA, Messengerbreast cancerceRNAfatty acid metabolismmolecular mechanismRNA sequencing

Identifiers

PMID35852149
PMCPMC9338430
OpenAlexW4285796654

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.