ArticleEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2024
The predictive value of serum lactate to forecast injury severity in trauma-patients increases taking age into account.
Article in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 6 citations in OpenAlex.
- Clinical Prognostic Modeling and Paired Blood-CSF Metabolomic Profiling for Outcome Prediction in Isolated Moderate-to-Severe Traumatic Brain Injury: Implications for Neurocritical Care Management.Journal of clinical medicine · 2026Article
- Interleukin-6 to identify mildly injured patients in the trauma resuscitation room - a clinical feasibility study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Does Arterial Blood Gas Analysis Predict an Adverse Course in Patients Admitted with Isolated Diaphyseal Femur Fractures?Revista brasileira de ortopedia · 2025Article
- [Does Arterial Blood Gas Analysis Predict an Adverse Course in Patients Admitted with Isolated Diaphyseal Femur Fractures?]Revista brasileira de ortopedia · 2025Article
- Further refinement of high standards of care- focus on polytrauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Early correction of base deficit decreases late mortality in polytrauma.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Article
- Combination of Lactate and Base Deficit Levels at Admission to Predict Mortality in Blunt Trauma Patients.Cureus · 2023Article
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Authors and funding
8 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundTwo-tier trauma team activation (TTA)-protocols often fail to safely identify severely injured patients. A possible amendment to existing triage scores could be the measurement of serum lactate. The aim of this study was to determine the ability of the combination of serum lactate and age to predict severe injuries (ISS > 15).
methodsWe conducted a retrospective cohort study in a single level one trauma center in a 20 months study-period and analyzed every trauma team activation (TTA) due to the mechanism of injury (MOI). Primary endpoint was the correlation between serum lactate (and age) and ISS and mortality. The validity of lactate (LAC) and lactate contingent on age (LAC + AGE) were assessed using the area under the curve (AUC) of the receiver operating characteristics (ROC) curve. We used a logistic regression model to predict the probability of an ISS > 15.
resultsDuring the study period we included 325 patients, 75 met exclusion criteria. Mean age was 43 years (Min.: 11, Max.: 90, SD: 18.7) with a mean ISS of 8.4 (SD: 8.99). LAC showed a sensitivity of 0.82 with a specificity of 0.62 with an optimal cutoff at 1.72 mmol/l to predict an ISS > 15. The AUC of the ROC for LAC was 0.764 (95% CI: 0.67-0.85). The LAC + AGE model provided a significantly improved predictive value compared to LAC (0.765 vs. 0.828, p < 0.001).
conclusionsThe serum lactate concentration is able to predict injury severity. The prognostic value improves significantly taking the patients age into consideration. The combination of serum lactate and age could be a suitable Ad-on to existing two-tier triage protocols to minimize undertriage. LEVEL OF EVIDENCE: Level IV, retrospective cohort study.
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