Evidence map›Paper›PMID 35856776›Full record

ArticlePediatric blood & cancer2022

Pediatric hematology providers' contraceptive practices for female adolescents and young adults with sickle cell disease: A national survey.

Megan A Askew, Arlene M Smaldone, Melanie A Gold, Kim Smith-Whitley, John J Strouse, Zhezhen Jin, Nancy S Green

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Pediatric blood & cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03462511 (Hydroxyurea Adherence for Personal Best in Sickle Cell Disease), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03462511 nacompletednot on this map

Hydroxyurea Adherence for Personal Best in Sickle Cell Disease (HABIT): Efficacy Trial

TypeinterventionalSponsorColumbia UniversityRan2018 to 2021Enrolled50ConditionsSickle Cell DiseaseArmsHABIT Intervention, Standard of Care, Education materials
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Understanding and treating menstruation associated sickle cell pain.Contraception and reproductive medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Megan A AskewDepartment of Pediatrics, Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.
Arlene M SmaldoneDepartment of Scholarship and Research, School of Nursing and College of Dental Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Melanie A GoldDepartment of Pediatrics, Division of Child and Adolescent Health, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.
Kim Smith-WhitleyDivision of Hematology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
John J StrouseDivision of Hematology, Department of Medicine, Duke University, Durham, North Carolina, USA.
Zhezhen JinDepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA.
Nancy S GreenDepartment of Pediatrics, Division of Pediatric Hematology, Oncology and Stem Cell Transplantation, Columbia University Irving Medical Center/New York-Presbyterian Hospital, New York, New York, USA.ORCID 0000-0002-9877-1561
NewYork–Presbyterian Hospital · USChildren's Hospital of Philadelphia · USColumbia University · USColumbia University Irving Medical Center · USDuke University · US

Funding

Reaching Communities through the Design of Information Visualizations (ReDIVis) Toolbox to Address COVID-19 Vaccine Hesitancy and Uptake.P30NR016587 · NINR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BAKKEN, SUZANNE, SMALDONE, ARLENE M · 2016 to 2022
$4.3M
Hydroxyurea Adherence for Personal Best in Sickle Cell Treatment: HABITR01NR017206 · NINR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREEN, NANCY S., SMALDONE, ARLENE M · 2017 to 2020
$2.9M
Burden and Risk of Neurological and Cognitive Impairment in Pediatric Sickle Cell Anemia in Uganda (BRAIN SAFE II)R01HD096559 · NICHD · GLOBAL HEALTH UGANDA, LTD · PI GREEN, NANCY S., IDRO, RICHARD IWA · 2019 to 2023
$2.2M
NICHD NIH HHS R01 HD096559NINR NIH HHS P30 NR016587NINR NIH HHS R01 NR017206
6 · The paper itself

Abstract

backgroundAdolescent and young adult (AYA) women with sickle cell disease (SCD) have increased pregnancy-related health risks and are prescribed potentially teratogenic medications, yet limited data are available regarding pediatric SCD provider contraceptive practices. We aimed to assess pediatric hematology providers' beliefs, practices, motivators, and barriers for providing contraceptive care to female AYAs with SCD.

methodsGuided by the Health Belief Model (HBM), we developed a 25-question, web-based survey to assess practices. Survey links were distributed nationwide to pediatric SCD and/or general hematology providers through their publicly available emails and by request to directors of U.S.-accredited Pediatric Hematology-Oncology fellowship programs for distribution to their SCD providers. Data analysis included descriptive statistics, chi-square analysis, and logistic regression.

resultsOf 177 respondents, 160 surveys meeting inclusion criteria were analyzed. Most providers reported counseling (77.5%) and referring female AYA patients for contraception (90.8%), but fewer reported prescribing contraception (41.8%). Proportionally fewer trainees provided counseling compared with established providers (54% vs. 85%, p < .001), with a similar trend for prescribing (p = .05). Prescription practices did not differ significantly by provider beliefs regarding potential teratogenicity of hydroxyurea. Key motivators included patient request and disclosure of sexual activity. Key barriers included inadequate provider training, limited visit time, and perceived patient/parent interest.

conclusionProvider contraceptive practices for female AYAs with SCD varied, especially by provider status. Health beliefs regarding teratogenic potential of hydroxyurea did not correlate with contraceptive practices. Clinical guidelines, provider training, and patient/parent decision-making tools may be tested to assess whether provider contraceptive practices could be improved.

Indexed as

Anemia, Sickle CellHematologyAdolescentChildContraceptionContraceptive AgentsFemaleHumansHydroxyureaPregnancyYoung AdultContraceptive AgentsHydroxyureaadolescentscontraceptionfemalessickle cell disease

Identifiers

PMID35856776
PMCPMC9623811
OpenAlexW4286210224

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.