Evidence map›Paper›PMID 35857835›Full record

ArticleScience advances2022

Measles and Nipah virus assembly: Specific lipid binding drives matrix polymerization.

Michael J Norris, Monica L Husby, William B Kiosses, Jieyun Yin, Roopashi Saxena, Linda J Rennick, Anja Heiner, Stephanie S Harkins, Rudramani Pokhrel, Sharon L Schendel and 9 more

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Measles virus reprograms CD4Frontiers in cell and developmental biology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. The "basics" of HIV-1 assembly.PLoS pathogens · 2024
    Article
  18. Article
  19. Article
  20. CHARMM-GUIJournal of chemical theory and computation · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Michael J NorrisCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-8325-5257
Monica L HusbyDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-0176-7241
William B KiossesCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-1832-9050
Jieyun YinCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-8841-431X
Roopashi SaxenaDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-5548-4773
Linda J RennickCenter for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0001-5974-6921
Anja HeinerInstitute of Virology, Philipps University Marburg, Marburg, Germany.
Stephanie S HarkinsCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-7825-4025
Rudramani PokhrelDepartment of Physics, Florida International University, Miami, FL 33199, USA.ORCID 0000-0002-7208-0420
Sharon L SchendelCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-5062-7261
Kathryn M HastieCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-3406-1210
Sara Landeras-BuenoCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Zhe Li SalieCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0003-2063-1013
Benhur LeeIcahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0760-1709
Prem P ChapagainDepartment of Physics, Florida International University, Miami, FL 33199, USA.ORCID 0000-0002-0999-4975
Andrea MaisnerInstitute of Virology, Philipps University Marburg, Marburg, Germany.
W Paul DuprexCenter for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.ORCID 0000-0003-1716-6376
Robert V StahelinDepartment of Medicinal Chemistry and Molecular Pharmacology, Purdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-5443-7863
Erica Ollmann SaphireCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0002-1206-7451
La Jolla Institute for Immunology · USPurdue University West Lafayette · USFlorida International University · USPhilipps University of Marburg · DEUniversity of Pittsburgh · USIcahn School of Medicine at Mount Sinai · US

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Aina E. Cohen, KEITH O HODGSON · 2020 to 2026
$43.3M
LIPID-PROTEIN INTERACTIONS IN VIRAL ASSEMBLY AND VIRUS LIKE PARTICLE FORMATIONR01AI081077 · NIAID · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL · 2009 to 2019
$3.5M
Tropism, pathogenicity, and potential for zoonotic spillover of emergent henipa- and henipa-like virusesR01AI123449 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR · 2016 to 2020
$2.7M
SUMO and ubiquitin modifications in henipavirus matrix trafficking and functionR01AI125536 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR · 2016 to 2020
$2.1M
Super-resolution confocal microscopeS10OD021831 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI LEY, KLAUS F. · 2017 to 2017
$566k
Request of a Nikon A1Rsi confocal microscopeS10OD027043 · OD · PURDUE UNIVERSITY · PI STAHELIN, ROBERT VIRGIL · 2019 to 2019
$538k
NIAID NIH HHS R01 AI081077NIAID NIH HHS R01 AI123449NIAID NIH HHS R01 AI125536NIGMS NIH HHS P30 GM133894NIH HHS S10 OD021831NIH HHS S10 OD027043
6 · The paper itself

Abstract

Measles virus, Nipah virus, and multiple other paramyxoviruses cause disease outbreaks in humans and animals worldwide. The paramyxovirus matrix (M) protein mediates virion assembly and budding from host cell membranes. M is thus a key target for antivirals, but few high-resolution structures of paramyxovirus M are available, and we lack the clear understanding of how viral M proteins interact with membrane lipids to mediate viral assembly and egress that is needed to guide antiviral design. Here, we reveal that M proteins associate with phosphatidylserine and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Identifiers

PMID35857835
PMCPMC9299542
OpenAlexW4285987594

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.