Evidence map›Paper›PMID 35858830›Full record

ArticleBMC gastroenterology2022

Segmental reversal of the distal small intestine in a short bowel syndrome model in piglets showed detrimental effect on weight gain.

Lasse Hartmann Schmidt, Jesper Stensig Aa, Bolette Hartmann, Gunvor Iben Madsen, Niels Qvist, Mark Bremholm Ellebæk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lasse Hartmann SchmidtResearch Unit for Surgery, Odense University Hospital, University of Southern Denmark, J. B. Winsløws Vej 4, 5000, Odense C, Denmark. Lassehartmannschmidt@gmail.com.ORCID http://orcid.org/0000-0002-6720-5911
Jesper Stensig AaResearch Unit for Surgery, Odense University Hospital, University of Southern Denmark, J. B. Winsløws Vej 4, 5000, Odense C, Denmark.ORCID http://orcid.org/0000-0002-0230-1531
Bolette HartmannDepartment of Medical Sciences, NNF Center for Basic Metabolic Research, Faculty of Health Science, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0001-8509-2036
Gunvor Iben MadsenResearch Unit for Pathology, Odense University Hospital, University of Southern Denmark, J. B. Winsløws Vej 4, 5000, Odense C, Denmark.
Niels QvistResearch Unit for Surgery, Odense University Hospital, University of Southern Denmark, J. B. Winsløws Vej 4, 5000, Odense C, Denmark.ORCID http://orcid.org/0000-0002-1113-195X
Mark Bremholm EllebækResearch Unit for Surgery, Odense University Hospital, University of Southern Denmark, J. B. Winsløws Vej 4, 5000, Odense C, Denmark.ORCID http://orcid.org/0000-0001-6550-7505
University of Southern Denmark · DKUniversity of Copenhagen · DK

Funding

Colitis-Crohn Foreningen Colitis-Crohn ForeningenFonden til Lægevidenskabens Fremme 17-L-0090)Odense Universitetshospital R49-A2513
6 · The paper itself

Abstract

backgroundTo investigate the effects of a reversed segment of the distal small intestine to improve weight gain in an experimental short bowel syndrome (SBS) model in piglets.

methodsTwenty-four piglets underwent resection of 70% of the distal small intestine. In half of the animals a conventional anastomosis was performed, and in the other half, the distal 25 cm of the remnant jejunum was reversed before the intestinal continuity was recreated. Weight was measured daily until day 28, where the animals were euthanized. Glucagon-Like Peptide-2 (GLP-2) and Glucose-dependent Insulinotropic Peptide (GIP) was measured pre- and postoperatively at day 28.

resultsThe group with reversal of small intestine had a significant lower weight gain at 5.26 ± 3.39 kg (mean ± SD) compared to the control group with 11.14 ± 3.83 kg (p < 0.05). In the control group greater villus height and crypt depth was found distally, and greater muscular thickness was found proximally in the intervention group. GLP-2 and GIP levels increased significantly in the control group.

conclusionsTreatment of short bowel syndrome with a reversed jejunal segment of 25 cm had a detrimental effect on the weight gain.

Indexed as

Short Bowel SyndromeAdaptation, PhysiologicalAnimalsDisease Models, AnimalGlucagon-Like Peptide 2Intestine, SmallSwineWeight GainGlucagon-Like Peptide 2GIPGLP-2Segmental reversalShort bowel syndromeShort gut syndrome

Identifiers

PMID35858830
PMCPMC9297615
OpenAlexW4285891531

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.