Evidence map›Paper›PMID 35858901›Full record

ArticleImmunity & ageing : I & A2022

Evaluation of T-cell aging-related immune phenotypes in the context of biological aging and multimorbidity in the Health and Retirement Study.

Ramya Ramasubramanian, Helen C S Meier, Sithara Vivek, Eric Klopack, Eileen M Crimmins, Jessica Faul, Janko Nikolich-Žugich, Bharat Thyagarajan

Abstract read
In one paragraph

Article in Immunity & ageing : I & A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Rethinking immune studies: population-level immune variations and the path forward.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Pooled it
  2. The role of CD8Frontiers in immunology · 2026
    Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. LatentBiomolecules · 2025
    Article
  11. Article
  12. Article
  13. Aging and immunity: the age-old tango.Genes & development · 2025
    Review
  14. Article
  15. Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. [Mechanism and significance of cell senescence induced by viral infection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ramya RamasubramanianDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Helen C S MeierInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA.
Sithara VivekDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA.
Eric KlopackLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Eileen M CrimminsLeonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
Jessica FaulInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI, USA.
Janko Nikolich-ŽugichDepartment of Immunobiology and the University of Arizona Center On Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, USA.
Bharat ThyagarajanDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. thya0003@umn.edu.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
USC/UCLA Center on Biodemography &Population HealthP30AG017265 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JENNIFER A AILSHIRE · 1999 to 2026
$17.9M
Biological Underpinnings of Socioeconomic Differentials in Health and MortalityR01AG060110 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M · 2018 to 2022
$2.6M
NIA NIH HHS P30 AG017265NIA NIH HHS R01 AG060110NIA NIH HHS R01 AG AG060110NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

backgroundCellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related immune phenotype (ARIP) characterized by decrease in naïve T-cells (T

methodsWe developed two ARIP indicators based on well understood age-related changes in T cell distribution: T

resultsCD8 + T

conclusionCD4 + T

Indexed as

Adaptive immunityBiological agingHealth and Retirement StudyImmune agingMultimorbidity

Identifiers

PMID35858901
PMCPMC9297609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.