ArticleNature2022
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- HvarAKR1B1-mediated tolerance in Hippodamia variegata: Deciphering the metabolic adaptation and fitness costs under prolonged starvation.Pest management science · 2026Article
- Gut Metabolism Links Precision Nutrition, Exercise, and Healthspan in Drosophila melanogaster.Aging cell · 2026Article
- Lysine Triggers Acute Oviposition by Activating the 20E-ETH-JH Signaling Cascade inInternational journal of molecular sciences · 2026Article
- Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine-ZBTB5-mTORC1 axis.Nature cell biology · 2026Article
- Article
- Gut metabolism links precision nutrition, exercise, and healthspan inbioRxiv : the preprint server for biology · 2025Article
- Serine tRNAs compete to regulate the mRNA translation of serine-sensitive codons.Science advances · 2025Article
- Differential cell survival outcomes in response to diverse amino acid stress.Life science alliance · 2025Article
- Stress-induced preference for antioxidants byProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Targeted cravings: Unraveling the drivers of nutrient-specific appetite.Current opinion in neurobiology · 2025Review
- The Molecular Basis of Amino Acids Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- PPDPF-mediated regulation of BCAA metabolism enhances mTORC1 activity and drives cholangiocarcinoma progression.Oncogene · 2025Article
- Article
- Molecular mechanism on autophagy associated cardiovascular dysfunction inFrontiers in cell and developmental biology · 2025Review
- The Emerging Role of Long Noncoding RNAs in Sorafenib Resistance Within Hepatocellular Carcinoma.Cancers · 2024Review
- Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3-their sensing mediator-is tumor suppressive.Cell death and differentiation · 2024Article
- Review
- Context-dependent impact of the dietary non-essential amino acid tyrosine onScience advances · 2024Article
- Rag-Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 5 institutions in 1 country.
Xin Gu *Whitehead Institute for Biomedical Research, Cambridge, MA, USA. xingu@mit.edu.ORCID http://orcid.org/0000-0002-3393-6927
Patrick Jouandin *Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Patrick_Jouandin@hms.harvard.edu.ORCID http://orcid.org/0000-0002-8656-7694
Pranav V LalgudiWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Rich BinariDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Max L ValensteinWhitehead Institute for Biomedical Research, Cambridge, MA, USA.
Michael A ReidDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6222-9538
Annamarie E AllenDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.
Nolan KamitakiDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0614-0189
Jason W LocasaleDepartment of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.ORCID http://orcid.org/0000-0002-7766-3502
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. perrimon@genetics.med.harvard.edu.ORCID http://orcid.org/0000-0001-7542-472X
David M Sabatini
Duke University · USHoward Hughes Medical Institute · USWhitehead Institute for Biomedical Research · USBroad Institute · USIIT@MIT · US
Funding
Women's Cancer Research ProgramP30CA014236 · NCI · DUKE UNIVERSITY · PI Laura Fish · 1985 to 2026
$174.8MMedical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0MTuberous Sclerosis-Pathway and PathogenesisP01CA120964 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI David J. Kwiatkowski · 2007 to 2026
$35.9MCenter for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human DiseaseRM1HG009490 · NHGRI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI Brittany S. Adamson, Martin Joseph Ankrah Aryee · 2017 to 2026
$22.7MTraining Program in Bioinformatics and Integrative GenomicsT32HG002295 · NHGRI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Peter J Park · 2001 to 2026
$15.8MCharacterization of the Insulin to Autophagy Pathway in MusclesR01AR057352 · NIAMS · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2010 to 2026
$8.2MRegulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MNovel Components of the mTORC1 and mTORC2 PathwaysR37AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SABATINI, DAVID M. · 2010 to 2019
$4.8MDietary methionine and cancerR01CA193256 · NCI · DUKE UNIVERSITY · PI LOCASALE, JASON W. · 2015 to 2023
$3.1MElucidating the role of GATOR2 in nutrient sensing by mTORC1F30CA228229 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI VALENSTEIN, MAX · 2018 to 2020
$150kExamining Biosynthesis and NAD+ Demand in the Warburg EffectF31CA232658 · NCI · DUKE UNIVERSITY · PI ALLEN, ANNAMARIE ELIZABETH · 2019 to 2021
$111kHoward Hughes Medical InstituteNCI NIH HHS F30 CA228229NCI NIH HHS F31 CA232658NCI NIH HHS P01 CA120964NCI NIH HHS P30 CA014236NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA193256NHGRI NIH HHS RM1 HG009490NHGRI NIH HHS T32 HG002295NIAID NIH HHS R37 AI047389NIAMS NIH HHS R01 AR057352NIGMS NIH HHS T32 GM007753
Abstract
Mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and metabolism in response to multiple nutrients, including the essential amino acid leucine
Indexed as
Adaptation, PhysiologicalDietDrosophila melanogasterDrosophila ProteinsLeucineSestrinsAnimal FeedAnimalsAutophagyFood PreferencesMechanistic Target of Rapamycin Complex 1Mutant ProteinsNeurogliaSignal TransductionDrosophila ProteinsLeucineMechanistic Target of Rapamycin Complex 1Mutant Proteinssesn protein, DrosophilaSestrins
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.