Evidence map›Paper›PMID 35860237›Full record

ReviewFrontiers in immunology2022

Inside-Out of Complement in Cancer.

Martin Kolev, Madhumita Das, Monica Gerber, Scott Baver, Pascal Deschatelets, Maciej M Markiewski

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Cancer therapy via neoepitope-specific monoclonal antibody cocktails.Cancer immunology, immunotherapy : CII · 2025
    Article
  10. The multiverse of CD46 and oncologic interactions.The Journal of clinical investigation · 2025
    Review
  11. Review
  12. Article
  13. Biomarkers of the Complement System in Cancer.Medeniyet medical journal · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Martin KolevDiscovery, Apellis Pharmaceuticals, Waltham, MA, United States.
Madhumita DasDiscovery, Apellis Pharmaceuticals, Waltham, MA, United States.
Monica GerberLegal Department, Apellis Pharmaceuticals, Waltham, MA, United States.
Scott BaverMedical Affairs, Apellis Pharmaceuticals, Waltham, MA, United States.
Pascal DeschateletsDiscovery, Apellis Pharmaceuticals, Waltham, MA, United States.
Maciej M MarkiewskiDepartment of Immunotherapeutics and Biotechnology, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Abilene, TX, United States.
Apellis Pharmaceuticals (United States) · USTexas Tech University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complement seems to suppress antitumor immunity

Indexed as

Complement System ProteinsNeoplasmsComplement ActivationHumansT-LymphocytesTumor MicroenvironmentComplement System Proteinsbiomarkerscancercomplosomeextracellular complementintracellular complementtherapytumor microenvironment

Identifiers

PMID35860237
PMCPMC9291441
OpenAlexW4283759911

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.