ReviewNature reviews. Disease primers2022
Chronic wounds.
Review in Nature reviews. Disease primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07745764 (INJECTHEAL- Profiling of Potential Wound Healing Therapeutics in Cellular Assays in the Presence of Wound Exudates), which is not on this map. Cited by 385 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INJECTHEAL- Profiling of Potential Wound Healing Therapeutics in Cellular Assays in the Presence of Wound Exudates
Who cites it
385 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Fungal detection, diagnostic approaches, and antifungal susceptibility in diabetic foot ulcers: a systematic review of recent evidence.Frontiers in fungal biology · 2026Pooled it
- Efficacy and safety of stem cell therapy in patients with chronic lower extremity ulcers: an umbrella review of systematic reviews and meta-analyses.Stem cell research & therapy · 2025Pooled it
- Implementing a primary care disease management concept for venous leg ulceration: findings of a mixed-methods process evaluation in the Ulcus Cruris Care trial.BMC health services research · 2026Trial
- Erbium:Yttrium Aluminium Garnet (Er:YAG) Laser Therapy Versus Sharp Debridement in the Management of Chronic Ulcers of the Lower Extremity: A Randomised Control Trial.International wound journal · 2025Trial
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Sprayable NIR/pH-responsive NSC/PF127 hydrogel loaded with MoO₂, ciprofloxacin, and FGF-2 for enhanced antibacterial and pro-regenerative infected wound healing.Drug delivery · 2026Article
- Janus electrospun nanofiber membranes from bio-based furan polyamides for antibacterial wound care.Bioactive materials · 2026Article
- Vitamins and Chronic Wounds: How Altered Pharmacokinetics and Comorbidities Contribute to Vitamin Deficiencies.Basic & clinical pharmacology & toxicology · 2026Review
- A sulfated chitosan-driven immune-ECM reprogramming strategy to break the vicious cycle of aged wound healing.Bioactive materials · 2026Article
- Calcifediol Treatment Improves Skin Wound Healing in Vitamin D Deficiency Obese Rats.Pharmaceutics · 2026Article
- A recent review on smart dressings for chronic wound management: from diagnosis to therapy.RSC advances · 2026Review
- GSH-derived carbon dot-mediated interfacial electron transfer modulates pH-Dependent redox catalysis of Ce-MOF nanozymes for wound healing.Redox biology · 2026Article
- Simultaneous broad-spectrum antibacterial and regenerative therapy for diabetic wounds using sonosensitive peptide composite hydrogel.Journal of nanobiotechnology · 2026Article
- Mortality trends of pressure ulcers and non-healing wounds in the United States, 1999-2024.Annals of medicine and surgery (2012) · 2026Article
- Python-controlled multimodal UV-VIS hyperspectral imaging system.Journal of biomedical optics · 2026Article
- Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Bioinspired "liquid-solid" biphasic dressing with exudate-gating transport, defense-attack antibacterial activity, and anti-adhesion property for exuding infected wound therapy.Bioactive materials · 2026Article
- Health Outcomes Led by Advanced Practice Nurses in Patients With Chronic Wounds: A Scoping Review.Journal of clinical nursing · 2026Article
- Advanced Nanomaterials for Chronic Wounds: M.O.I.S.T. Concept-Driven Design Strategy.Advanced healthcare materials · 2026Review
- Use of Oxygen-Enriched Oil Dressings in Wound Management: A Scoping Review.Journal of clinical medicine · 2026Review
325 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Chronic wounds are characterized by their inability to heal within an expected time frame and have emerged as an increasingly important clinical problem over the past several decades, owing to their increasing incidence and greater recognition of associated morbidity and socio-economic burden. Even up to a few years ago, the management of chronic wounds relied on standards of care that were outdated. However, the approach to these chronic conditions has improved, with better prevention, diagnosis and treatment. Such improvements are due to major advances in understanding of cellular and molecular aspects of basic science, in innovative and technological breakthroughs in treatment modalities from biomedical engineering, and in our ability to conduct well-controlled and reliable clinical research. The evidence-based approaches resulting from these advances have become the new standard of care. At the same time, these improvements are tempered by the recognition that persistent gaps exist in scientific knowledge of impaired healing and the ability of clinicians to reduce morbidity, loss of limb and mortality. Therefore, taking stock of what is known and what is needed to improve understanding of chronic wounds and their associated failure to heal is crucial to ensuring better treatments and outcomes.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.