ArticleBioprocess and biosystems engineering2022
Optimisation of the fermentation media to enhance the production of the bioactive isomer of vitamin menaquinone-7.
Article in Bioprocess and biosystems engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Machine learning-optimized bioprocess for macroidin production by Lysinibacillus macroides and its biomedical applications.Bioprocess and biosystems engineering · 2025Article
- Regulation and induction of fungal secondary metabolites: a comprehensive review.Archives of microbiology · 2025Review
- Vitamin K (Menaquinone) from marine Kocuria sp. RAM1: optimization, characterization and potential in vitro biological activities.Microbial cell factories · 2025Article
- A bioprocess optimization study to enhance the production of Menaquinone-7 using Bacillus subtilis MM26.Microbial cell factories · 2025Article
- Article
- Production of menaquinone - 7 byJournal of food science and technology · 2025Article
- Simultaneous Production of MK-7 and Iturin A by Bacillus velezensis ND.Applied biochemistry and biotechnology · 2025Article
- The Impact of Amine-Functionalised Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Profile and Production of the Bioactive Isomer.Molecular biotechnology · 2024Article
- Enhancing menaquinone-7 biosynthesis through strengthening precursor supply and product secretion.Bioprocess and biosystems engineering · 2024Article
- The Effect of Iron Oxide Nanoparticles on the Menaquinone-7 Isomer Composition and Synthesis of the Biologically Significant All-Nanomaterials (Basel, Switzerland) · 2023Article
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Authors and funding
3 authors.
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Abstract
Menaquinone-7 (MK-7) offers significant health benefits; however, only the all-trans form is biologically active. MK-7 produced through fermentation can occur as all-trans and cis isomers, and the therapeutic value of the resulting MK-7 is exclusively determined by the quantity of the all-trans isomer. Therefore, this study aimed to investigate the effect of the media composition on the isomer profile obtained from fermentation and determine the optimum media combination to increase the concentration of the all-trans isomer and diminish the production of cis MK-7. For this purpose, design of experiments (DOE) was used to screen the most effective nutrients, and a central composite face-centred design (CCF) was employed to optimise the media components. The optimum media consisted of 1% (w/v) glucose, 2% (w/v) yeast extract, 2% (w/v) soy peptone, 2% (w/v) tryptone, and 0.1% (w/v) CaCl
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