Evidence map›Paper›PMID 35867711›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2022

Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function.

Pei-Wen Liu, Gregory L Martin, Weiyu Lin, Wanting Huang, Suchita Pande, Mark J Aronovitz, Roger J Davis, Robert M Blanton

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Pei-Wen LiuMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Gregory L MartinMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Weiyu LinMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.ORCID 0000-0003-0755-7277
Wanting HuangMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Suchita PandeMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Mark J AronovitzMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.
Roger J DavisProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts.ORCID 0000-0002-0130-1652
Robert M BlantonMolecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts.ORCID 0000-0002-6837-2076
Tufts University · USTufts Medical Center · USUniversity of Massachusetts Chan Medical School · US

Funding

Investigating Mixed Lineage Kinase 3 as a blood pressure-independent protein kinase G1 effector in heart failureR01HL162919 · NHLBI · TUFTS MEDICAL CENTER · PI Robert Morris Blanton · 2022 to 2026
$3.9M
Metabolic Stress SignalingR01DK107220 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2016 to 2023
$3.6M
Novel Protein Kinase GI Substrates in Cardiac Remodeling and Blood Pressure ControlR01HL131831 · NHLBI · TUFTS MEDICAL CENTER · PI BLANTON, ROBERT MORRIS · 2016 to 2020
$2.1M
NHLBI NIH HHS R01 HL131831NHLBI NIH HHS R01 HL162919NIDDK NIH HHS R01 DK107220
6 · The paper itself

Abstract

Mixed lineage kinase 3 (MLK3) modulates blood pressure and left ventricular function, but the mechanisms governing these effects remain unclear. In the current study, we therefore investigated the role of the MLK3 Cdc42/Rac interactive binding (CRIB) domain in cardiovascular physiology. We examined baseline and left ventricular pressure overload responses in a MLK3 CRIB mutant (

Indexed as

CardiomegalyVentricular Function, LeftAnimalsBlood PressureFemaleHypertrophy, Left VentricularMaleMAP Kinase Kinase KinasesMiceMice, Inbred C57BLMitogen-Activated Protein Kinase Kinase Kinase 11Protein DomainsVentricular RemodelingMAP Kinase Kinase KinasesMitogen-Activated Protein Kinase Kinase Kinase 11cardiac hypertrophyheart failurehypertensionmixed lineage kinasemolecular signaling

Identifiers

PMID35867711
PMCPMC9448288
OpenAlexW4286587071

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.