Evidence map›Paper›PMID 35871663›Full record

ArticlePflugers Archiv : European journal of physiology2022

Sexually dimorphic effects of prenatal diazepam exposure on respiratory control and the monoaminergic system of neonate and young rats.

Carlos Aparecido da Silva Junior, Luís Gustavo A Patrone, Vivian Biancardi, Heloísa H Vilela-Costa, Danuzia A Marques, Caroline Cristina-Silva, Kaoma Stephani da Costa Silva, Kênia C Bícego, Raphael E Szawka, Luciane H Gargaglioni

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Prenatal depression and psychotropics in offspring asthma and atopic dermatitis.Journal of the Chinese Medical Association : JCMA · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Carlos Aparecido da Silva JuniorDepartment of Animal Morphology and Physiology, FCAV - UNESP - São Paulo State University, Jaboticabal, SP, Brazil.
Luís Gustavo A PatroneDepartment of Animal Morphology and Physiology, FCAV - UNESP - São Paulo State University, Jaboticabal, SP, Brazil.
Vivian BiancardiDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Al, Canada.
Heloísa H Vilela-CostaDepartment of Biochemistry, Pharmacology and Physiology, Institute of Biological and Natural Sciences, Federal University of Triangulo Mineiro, Uberaba, MG, Brazil.
Danuzia A MarquesDepartment of Pediatrics, Québec Heart and Lung Institute, Université Laval, Québec, QC, Canada.
Caroline Cristina-SilvaDepartment of Animal Morphology and Physiology, FCAV - UNESP - São Paulo State University, Jaboticabal, SP, Brazil.
Kaoma Stephani da Costa SilvaDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais - UFMG, Belo Horizonte, MG, Brazil.
Kênia C BícegoDepartment of Animal Morphology and Physiology, FCAV - UNESP - São Paulo State University, Jaboticabal, SP, Brazil.
Raphael E SzawkaDepartment of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais - UFMG, Belo Horizonte, MG, Brazil.
Luciane H GargaglioniDepartment of Animal Morphology and Physiology, FCAV - UNESP - São Paulo State University, Jaboticabal, SP, Brazil. luciane.gargaglioni@unesp.br.
Universidade Estadual Paulista (Unesp) · BRUniversidade Federal de Minas Gerais · BRUniversidade Federal do Triângulo Mineiro · BRUniversité Laval · CAUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy is highly affected by anxiety disorders, which may be treated with benzodiazepines, especially diazepam (DZP), that can cross the placental barrier and interact with the fetal GABAergic system. We tested whether prenatal exposure to DZP promotes sex-specific postnatal changes in the respiratory control of rats. We evaluated ventilation ([Formula: see text]) and oxygen consumption ([Formula: see text] O

Indexed as

Carbon DioxideDiazepam3,4-Dihydroxyphenylacetic AcidAcetatesAnimalsDopamineFemaleHydroxyindoleacetic AcidHypercapniaHypoxiaMaleNorepinephrinePlacentaPregnancyRats3,4-Dihydroxyphenylacetic AcidAcetatesCarbon DioxideDiazepamDopamineHydroxyindoleacetic AcidNorepinephrineBenzodiazepineBreathingChemosensitivityDevelopmentGABA

Identifiers

PMID35871663
OpenAlexW4287009080

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.