Evidence map›Paper›PMID 35873177›Full record

ArticleNature aging2022

Leveraging technology to personalize cognitive enhancement methods in aging.

David A Ziegler, Joaquin A Anguera, Courtney L Gallen, Wan-Yu Hsu, Peter E Wais, Adam Gazzaley

Abstract read
In one paragraph

Article in Nature aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. A pilot study of a targeted cognitive intervention for cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Trial
  2. Review
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  11. Closed-Loop Systems and Real-Time Neurofeedback in Mindfulness Meditation Research.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025
    Review
  12. Review
  13. Fine Tuning of an Advanced Planner for Cognitive Training of Older Adults.European journal of investigation in health, psychology and education · 2025
    Article
  14. Review
  15. Article
  16. Review
  17. Article
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  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David A ZieglerDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.  .ORCID 0000-0002-2280-7417
Joaquin A AngueraDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.  .
Courtney L GallenDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.  .
Wan-Yu HsuDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.  .
Peter E WaisDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.  .
Adam GazzaleyDepartment of Neurology, University of California San Francisco, San Francisco, CA, USA.  .ORCID 0000-0002-1232-9431

Funding

Optimizing a closed-loop digital meditation intervention for remediating cognitive decline and reducing stress in older adultsR01AG076668 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ADAM H GAZZALEY, David A Ziegler · 2022 to 2026
$5.8M
Enhancing Cognitive Control in Older Adults with Complementary InterventionsR01AG049424 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AREAN, PATRICIA A., GAZZALEY, ADAM H · 2015 to 2019
$2.9M
A Computerized Intervention Targeting Cognitive Control Network Deficits in DepressionR33MH110509 · NIMH · UNIVERSITY OF WASHINGTON · PI ANGUERA, JOAQUIN A, AREAN, PATRICIA A. · 2018 to 2020
$2.0M
A Computerized Intervention Targeting Cognitive Control Network Deficits in DepressionR61MH110509 · NIMH · UNIVERSITY OF WASHINGTON · PI ANGUERA, JOAQUIN A, AREAN, PATRICIA A. · 2016 to 2018
$1.3M
Multi-modal Study of Cognitive and Neural Differences in Media MultitaskersR56MH111672 · NIMH · STANFORD UNIVERSITY · PI ANGUERA, JOAQUIN A, WAGNER, ANTHONY D · 2017 to 2018
$1.2M
Neural Mechanisms of Learning to Resolve Interference in Younger and Older AdultsR01AG040333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAZZALEY, ADAM H · 2012 to 2016
$1.2M
Can Metal Health Apps Work in the Real World? A Feasibility Pilot StudyR34MH100466 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANGUERA, JOAQUIN A, GAZZALEY, ADAM H · 2013 to 2015
$818k
Neural Correlates of Discrimination and Generalization in Recognition MemoryR00AG043557 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAIS, PETER EDWARD · 2016 to 2018
$739k
Scaling a smarter and more efficient intervention: Evaluating the feasibility of disseminating a novel mobile app platform to treat depressionR34MH110583 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANGUERA, JOAQUIN A, AREAN, PATRICIA A. · 2016 to 2018
$580k
Enhancing cognitive control abilities using mobile technology in a senior living communityR21AG058896 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANGUERA, JOAQUIN A, GAZZALEY, ADAM H · 2019 to 2020
$441k
Building a shared infrastructure for cognitive assessment in the service of cognitive training researchR21AG074497 · NIA · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI ANGUERA, JOAQUIN A, JAEGGI, SUSANNE M · 2021 to 2022
$429k
Mechanisms of self-regulation of internal distractionR21AG041071 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAZZALEY, ADAM H · 2011 to 2012
$382k
NIA NIH HHS K99 AG043557NIA NIH HHS R00 AG043557NIA NIH HHS R01 AG040333NIA NIH HHS R01 AG049424NIA NIH HHS R01 AG076668NIA NIH HHS R21 AG041071NIA NIH HHS R21 AG058896NIA NIH HHS R21 AG074497NIMH NIH HHS R33 MH110509NIMH NIH HHS R34 MH100466NIMH NIH HHS R34 MH110583NIMH NIH HHS R56 MH111672NIMH NIH HHS R61 MH110509
6 · The paper itself

Abstract

As population aging advances at an increasing rate, efforts to help people maintain or improve cognitive function late in life are critical. Although some studies have shown promise, the question of whether cognitive training is an effective tool for improving general cognitive ability remains incompletely explored, and study results to date have been inconsistent. Most approaches to cognitive enhancement in older adults have taken a 'one size fits all' tack, as opposed to tailoring interventions to the specific needs of individuals. In this Perspective, we argue that modern technology has the potential to enable large-scale trials of public health interventions to enhance cognition in older adults in a personalized manner. Technology-based cognitive interventions that rely on closed-loop systems can be tailored to individuals in real time and have the potential for global testing, extending their reach to large and diverse populations of older adults. We propose that the future of cognitive enhancement in older adults will rely on harnessing new technologies in scientifically informed ways.

Indexed as

AgingCognitionCognitive TrainingTechnologyAgedHumans

Identifiers

PMID35873177
PMCPMC9302894

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.