Evidence map›Paper›PMID 35874495›Full record

ArticleIBRO neuroscience reports2022

Ruth Edwige Kemadjou Dibacto, Dany Joël Ngassa Ngoumen, Fils Armand Ella, Jules Vidal Kamga Nanhah, Bruno Dupon Akamba Ambamba, Pauline Vervaine Hagbe, Martin Fonkoua, Damaris Enyegue Mandob, René Samuel Minka, Judith Laure Ngondi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IBRO neuroscience reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ruth Edwige Kemadjou DibactoDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Dany Joël Ngassa NgoumenDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Fils Armand EllaDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Jules Vidal Kamga NanhahDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Bruno Dupon Akamba AmbambaDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Pauline Vervaine HagbeDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Martin FonkouaDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Damaris Enyegue MandobDepartment of Biological Sciences, Higher Teacher's Training College, University of Yaounde I, Yaounde, Cameroon.
René Samuel MinkaDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Judith Laure NgondiDepartment of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Université de Yaoundé I · CMMinistry of Scientific Research and Innovation · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Many neurodegenerative such as Alzheimer's disease (AD) are characterized by cholinergic dysfunction and oxidative stress which is a key event in neuronal death process. Thus, anticholinesterase and anti-oxidation compounds are two promising strategies in the development of AD drugs. Beyond their culinary use, spices are today studies for health purpose. In this study, some spices consumed in Cameroon were evaluated for their anticholinesterase and neuroprotective effects. Methods: Colorimetric methods were used to determine total flavonoid and alkaloid content of a combinated extract (hydroethanolic + ethanolic extracts) of different selected spices. Aftermaths, anti-cholinesterase activity of spice extract was carried out using Ellman's method. Finally, neuroprotective effects performed on human SK-N-SH cells stressed with H Results: Flavonoid content of spices extract were ranged from 22.94 to 32.01 mg EQ/g DM and alkaloid content were ranged from 320 to 896 mg EQu/g DM. Among the spices studied, Conclusion: The present results reveal that selected spices consumed in Cameroon have good anticholinesterase activity as well as neuroprotective effect on SK-N-SH which may provide new natural compounds that could help in the management of Alzheimer's disease.

Indexed as

ABTS, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)AcetylcholinesteraseAchE, acetylcholine esteraseAD, Alzheimer diseaseAntioxidantDPPH, 1, 1-Diphenyl-2-PicrilhydrazylEQ, equivalentFDA, food and drug administrationH2O2IC, inhibitory concentrationIV, intravenousLDH, lactate dehydrogenaseNAD, nicotinamide adenosine dinucleotideNeuroprotectiveOS, oxidative stressROS, reactive oxygen species, TAC, total antioxidant capacitySK-N-SHSpices

Identifiers

PMID35874495
PMCPMC9305342
OpenAlexW4285400601

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.