Evidence map›Paper›PMID 35874965›Full record

ArticleAdvances in physics: X2022

Computational methods and theory for ion channel research.

C Guardiani, F Cecconi, L Chiodo, G Cottone, P Malgaretti, L Maragliano, M L Barabash, G Camisasca, M Ceccarelli, B Corry and 3 more

Open access · goldAbstract read
In one paragraph

Article in Advances in physics: X, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

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  5. From Atoms to Neuronal Spikes: A Multiscale Simulation Framework.Journal of chemical theory and computation · 2026
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  7. From Atoms to Neuronal Spikes: A Multi-Scale Simulation Framework.bioRxiv : the preprint server for biology · 2025
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  8. Review
  9. Dynamics and Interplay of the Binding Pockets in the Glycine Receptor.Journal of chemical information and modeling · 2025
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  12. Evaluation of Au(III) complexes as Plasmodium falciparum aquaglyceroporin (PfAQP) inhibitors by in silico and in vitro methods.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2024
    Article
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  14. Potential Targeting Mechanisms for Bone-Directed Therapies.International journal of molecular sciences · 2024
    Review
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 12 institutions in 4 countries.

C GuardianiDipartimento di Ingegneria Meccanica e Aerospaziale, Sapienza Università di Roma, Rome, Italy.
F CecconiCNR - Istituto dei Sistemi Complessi, Rome, Italy and Istituto Nazionale di Fisica Nucleare, INFN, Roma1 section. 00185, Roma, Italy.
L ChiodoDepartment of Engineering, Campus Bio-Medico University, Rome, Italy.
G CottoneDepartment of Physics and Chemistry-Emilio Segrè, University of Palermo, Palermo, Italy.
P MalgarettiHelmholtz Institute Erlangen-Nürnberg for Renewable Energy (IEK-11), Forschungszentrum Jülich, Erlangen, Germany.
L MaraglianoDepartment of Life and Environmental Sciences, Polytechnic University of Marche, Ancona, Italy, and Center for Synaptic Neuroscience and Technology, Istituto Italiano di Tecnologia, Genova, Italy.
M L BarabashDepartment of Materials Science and Nanoengineering, Rice University, Houston, TX 77005, USA.
G CamisascaDipartimento di Ingegneria Meccanica e Aerospaziale, Sapienza Università di Roma, Rome, Italy.
M CeccarelliDepartment of Physics and CNR-IOM, University of Cagliari, Monserrato 09042-IT, Italy.
B CorryResearch School of Biology, The Australian National University, Canberra, ACT 2600, Australia.
R RothInstitut Für Theoretische Physik, Eberhard Karls Universität Tübingen, Tübingen, Germany.
A GiacomelloDipartimento di Ingegneria Meccanica e Aerospaziale, Sapienza Università di Roma, Rome, Italy.
B RouxDepartment of Biochemistry & Molecular Biology, University of Chicago, Chicago IL, USA.
Sapienza University of Rome · ITAustralian National University · AUForschungszentrum Jülich · DEIstituto Nazionale di Fisica Nucleare · ITItalian Institute of Technology · ITRice University · USRoma Tre University · ITUniversità Campus Bio-Medico · ITUniversity of Cagliari · ITUniversity of Chicago · USUniversity of Palermo · ITUniversity of Tübingen · DE

Funding

Computational Studies of Ion Channels - Resubmission 01R01GM062342 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI ROUX, BENOIT · 2001 to 2022
$8.7M
NIGMS NIH HHS R01 GM062342
6 · The paper itself

Abstract

Ion channels are fundamental biological devices that act as gates in order to ensure selective ion transport across cellular membranes; their operation constitutes the molecular mechanism through which basic biological functions, such as nerve signal transmission and muscle contraction, are carried out. Here, we review recent results in the field of computational research on ion channels, covering theoretical advances, state-of-the-art simulation approaches, and frontline modeling techniques. We also report on few selected applications of continuum and atomistic methods to characterize the mechanisms of permeation, selectivity, and gating in biological and model channels.

Indexed as

biomimetic nanoporesconductancecontinuum modelsgatingIon channelsmachine learningmolecular dynamicsrare eventsselectivity

Identifiers

PMID35874965
PMCPMC9302924
OpenAlexW4283079448

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.