Evidence map›Paper›PMID 35877914›Full record

ArticleMembranes2022

Suelen Cristina Sartoretto, Natalia de Freitas Gens, Rodrigo Figueiredo de Brito Resende, Adriana Terezinha Neves Novellino Alves, Rafael Cury Cecato, Marcelo José Uzeda, Jose Mauro Granjeiro, Monica Diuana Calasans-Maia, Jose Albuquerque Calasans-Maia

Open access · goldAbstract read
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Suelen Cristina SartorettoOral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.ORCID 0000-0002-8414-3775
Natalia de Freitas GensGraduate Program, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.ORCID 0000-0002-4485-4935
Rodrigo Figueiredo de Brito ResendeOral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.
Adriana Terezinha Neves Novellino AlvesLaboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.
Rafael Cury CecatoImplant Dentistry Center for Education and Research on Dental Implants (CEPID), Department of Dentistry, Federal University of Santa Catarina (UFSC), Florianópolis 88000-000, Santa Catarina, Brazil.
Marcelo José UzedaOral Surgery Department, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.ORCID 0000-0001-9148-9929
Jose Mauro GranjeiroLaboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.
Monica Diuana Calasans-MaiaLaboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.ORCID 0000-0001-5759-7926
Jose Albuquerque Calasans-MaiaLaboratory for Clinical Research in Dentistry, Dentistry School, Fluminense Federal University, Niteroi 24020-140, Rio de Janeiro, Brazil.ORCID 0000-0002-1498-726X
Universidade Federal Fluminense · BRUniversidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe degree of biodegradation and the inflammatory response of membranes employed for guided bone regeneration directly impact the outcome of this technique. This study aimed to evaluate four different experimental versions of Poly (L-lactate-co-Trimethylene Carbonate) (PTMC) + Poly (L-lactate-co-glycolate) (PLGA) membranes, implanted in mouse subcutaneous tissue, compared to a commercially available membrane and a Sham group.

methodsSixty Balb-C mice were randomly divided into six experimental groups and subdivided into 1, 3, 6 and 12 weeks (n = 5 groups/period). The membranes (1 cm

resultsG1 and G4 allowed tissue adhesion and the permeation of inflammatory cells over time and showed greater phagocytic activity and permeability. G2 and G3 detached from the tissue in one and three weeks; however, in the more extended periods, they presented a rectilinear and homogeneous aspect and were not absorbed. G2 had a major inflammatory reaction. G5 was almost completely absorbed after 12 weeks.

conclusionsThe membranes are considered biocompatible. G5 showed a higher degree of biosorption, followed by G1 and G4. G2 and G3 are considered non-absorbable in the studied periods.

Indexed as

biocompatibilitymembranesmicePLGAPTMCsubcutaneous

Identifiers

PMID35877914
PMCPMC9324035
OpenAlexW4285593934

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.