SynthesisGerontology2022
Evaluation of Appendicular Muscle Mass in Sarcopenia in Older Adults Using Ultrasonography: A Systematic Review and Meta-Analysis.
Synthesis in Gerontology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Low lean mass and all-cause mortality risk in the middle-aged and older population: a dose-response meta-analysis of prospective cohort studies.Frontiers in medicine · 2025Pooled it
- Artificial intelligence-driven assessment of sarcopenia in orthopedic geriatrics: technical progress and clinical implications.Frontiers in endocrinology · 2026Review
- Relaxed Stiffness of Lower Extremity Muscles and Step Width Variability as Key Differences Between Sarcopenia and Dynapenia in Community-Dwelling Older Adults: A Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- Determination of Ultrasound Reference Values for Diagnosing Low Muscle Mass in Older Chinese Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Evaluation of Muscle Mass and Quality With an AI-Based Muscle Ultrasound Imaging System in Patients at Risk of Malnutrition.Journal of cachexia, sarcopenia and muscle · 2025Observational
- Muscle oxygen saturation stratification by photoacoustic imaging in diabetic sarcopenia: Association with disease status.Photoacoustics · 2025Article
- Establishing Ultrasound Thresholds for Sarcopenia Diagnosis in Older Brazilian Adults.Muscles (Basel, Switzerland) · 2025Article
- Review
- Investigation of the Impact of Body Mass Index in the 20s on Chronic Metabolic Diseases and Their Progression Rate After the Age of 65 Years.Journal of Korean medical science · 2025Article
- Rectus femoris ultrasound identifies sarcopenia and predicts poor outcomes in patients with acute decompensation of cirrhosis.JHEP reports : innovation in hepatology · 2025Article
- Qualitative and quantitative ultrasonographic assessment of muscle and its association with comprehensive geriatric assessment results among older patients scheduled for abdominal surgery.Journal of ultrasonography · 2025Article
- Normative data of ultrasound quadriceps rectus femoris geometric values. The ECOSARC-2 Study.The journal of nutrition, health & aging · 2025Article
- Article
- Association between diaphragm excursion and whole-body muscle mass in older adults: an observational study.Scientific reports · 2025Observational
- Alkaline Phosphatase as a Potential Biomarker of Muscle Function: A Pilot Study in Patients with Hypophosphatasia.International journal of molecular sciences · 2025Article
- Definition and diagnosis of sarcopenia: Asia-Pacific perspectives.Osteoporosis and sarcopenia · 2025Review
- Equations for Assessing Body Composition by Ultrasound in Older Adults: A Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- A Causal Effect of Serum 25(OH)D Level on Appendicular Muscle Mass: Evidence From NHANES Data and Mendelian Randomization Analyses.Journal of cachexia, sarcopenia and muscle · 2025Article
- Low appendicular skeletal muscle mass is associated with the risk of mortality among adults in the United States.Scientific reports · 2025Article
- Ultrasonographic assessment of thenar muscles for diagnosing sarcopenic obesity in patients with schizophrenia.Frontiers in psychiatry · 2025Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe measurement of appendicular muscle mass is essential for the diagnosis of sarcopenia. Ultrasonography is an accurate and convenient method used to evaluate muscle mass.
objectiveThe aim of the study was to evaluate the diagnostic value of ultrasonography for appendicular muscle mass in sarcopenia in older adults and find out proper ultrasound parameters.
methodsMedline, Embase, Cochrane, and Web of Science databases were searched for relevant articles. Published studies on the validity and/or reliability of ultrasonography for quantifying muscle mass of the limbs in sarcopenia in the older population were included. A systematic review was conducted based on specific muscles and reference methods. A meta-analysis was conducted to assess the validity and reliability of the ultrasonography.
resultsForty articles were included in this review. There were nine, nine, nine, and four studies included in the qualitative synthesis for a diagnostic test, correlation coefficient, intra-class reliability, and inter-class reliability, respectively. The diagnostic value of rectus femoris (RF) or gastrocnemius (GM) thickness on ultrasonography for sarcopenia or low muscle mass was moderate (the area under summary receiver operating characteristic curve [SROC] = 0.76, 95% confidence interval [CI]: 0.72-0.79, SROC = 0.80, 95% CI: 0.76-0.83, respectively). The pooled correlation between muscle mass on dual-energy X-ray (DXA) or bioelectrical impedance analysis (BIA) and muscle thickness (MT) on ultrasound was moderate (r = 0.56, 95% CI: 0.49-0.62). There was a low-to-moderate correlation between muscle mass on DXA or BIA and cross-sectional area (CSA) on ultrasound (r = 0.267-0.584). The correlation was high to very high between muscle mass from DXA and the ultrasound-predicted formula (r = 0.85-0.963). The CSA from ultrasound had a high or very high correlation with that from computed tomography or magnetic resonance imaging (r = 0.826, intra (inter)-correlation coefficient [ICC] = 0.998-0.999). The respective meta-analyses showed good inter-rater and intra-rater reliabilities (ICC > 0.9).
conclusionUltrasonography is a reliable and valid diagnostic method for the quantitative assessment of appendicular muscle mass in sarcopenia in older people. The thickness and CSA of the RF or GM seem to be proper ultrasound parameters to predict muscle mass in sarcopenia. Multicenter studies with large samples and the application of new ultrasonic techniques will be the future research directions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.