Evidence map›Paper›PMID 35879332›Full record

ArticleNature communications2022

Integrin α3β1 promotes vessel formation of glioblastoma-associated endothelial cells through calcium-mediated macropinocytosis and lysosomal exocytosis.

Eunnyung Bae, Ping Huang, Gaёlle Müller-Greven, Dolores Hambardzumyan, Andrew Edward Sloan, Amy S Nowacki, Nicholas Marko, Cathleen R Carlin, Candece L Gladson

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Eunnyung BaeDepartment of Cancer Biology, Cleveland, Clinic, Cleveland, OH, USA.ORCID http://orcid.org/0000-0003-0653-3126
Ping HuangDepartment of Cancer Biology, Cleveland, Clinic, Cleveland, OH, USA.
Gaёlle Müller-GrevenDepartment of Cancer Biology, Cleveland, Clinic, Cleveland, OH, USA.
Dolores HambardzumyanDepartments of Oncological Sciences and Neurosurgery, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Andrew Edward SloanDepartment of Neurosurgery, Seidman Cancer Center, Cleveland, OH, USA.
Amy S NowackiDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Nicholas MarkoDepartment of Neurosurgery, LewisGale Medical Center, Salem, VA, USA.
Cathleen R CarlinUniversity Hospital-Cleveland Medical Center and the Case Comprehensive Cancer Center, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
Candece L GladsonDepartment of Cancer Biology, Cleveland, Clinic, Cleveland, OH, USA. gladsoc@ccf.org.ORCID http://orcid.org/0000-0002-7651-4046
Cleveland Clinic · USIcahn School of Medicine at Mount Sinai · USLewis Gale Medical Center · USUniversity Hospitals Seidman Cancer Center · USUniversity School · US

Funding

Endocytic Trafficking of ADCs in GBM cancer stem-like cellsR01NS111981 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI CATHLEEN R CARLIN, Candece L Gladson · 2019 to 2026
$2.3M
Mechanisms Promoting Angiogenesis in GlioblastomaR01CA175120 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI GLADSON, CANDECE L · 2013 to 2017
$1.7M
Role of epithelial cell intracellular trafficking in the innate immune response to adenovirus infectionR01GM138696 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI CARLIN, CATHLEEN R · 2021 to 2024
$1.5M
Leica TCS SP8 Confocal Microscope for a Core FacilityS10OD019972 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI DRAZBA, JUDY · 2015 to 2015
$544k
NCI NIH HHS R01 CA175120NIGMS NIH HHS R01 GM138696NIH HHS S10 OD019972NINDS NIH HHS R01 NS111981
6 · The paper itself

Abstract

Therapeutic targeting of angiogenesis in glioblastoma has yielded mixed outcomes. Investigation of tumor-associated angiogenesis has focused on the factors that stimulate the sprouting, migration, and hyperproliferation of the endothelial cells. However, little is known regarding the processes underlying the formation of the tumor-associated vessels. To address this issue, we investigated vessel formation in CD31

Indexed as

GlioblastomaIntegrin alpha3beta1CalciumCell MovementEndothelial CellsExocytosisHumansLysosomesNeovascularization, PathologicCalciumIntegrin alpha3beta1

Identifiers

PMID35879332
PMCPMC9314429
OpenAlexW4287091853

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.