ArticleScientific reports2022
Altered genome-wide hippocampal gene expression profiles following early life lead exposure and their potential for reversal by environmental enrichment.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic Review and Transcriptomic Meta-analysis of Environmental Enrichment Reveal Core Molecular Programs of Brain Plasticity.Molecular neurobiology · 2026Pooled it
- The Impact of Childhood Cognitively Stimulating Activities on the Association between Prenatal and Early Postnatal Lead Exposure and Later Adulthood Cognitive Function.Environmental health perspectives · 2026Article
- Multi-omics characterization of chronic social defeat stress recall-activated nuclei in Arc-GFP mice.Molecular psychiatry · 2026Article
- Impact of air pollution and occupational inhalation exposures on neurodegenerative disorders: An epigenetic perspective.iScience · 2025Review
- Developmental lead exposure and aggression in male rats: Influences of maternal care and environmental enrichment.Toxicology reports · 2025Article
- Unmasking Lead Exposure and Neurotoxicity: Epigenetics, Extracellular Vesicles, and the Gut-Brain Connection.Indian journal of clinical biochemistry : IJCB · 2025Article
- Influences of quality of maternal care and environmental enrichment on associative memory function in rats with early life lead exposure.Brain and behavior · 2024Article
- Cross-sectional and prospective associations of early childhood circulating metals with early and mid-childhood cognition in the Project Viva cohort.Environmental research · 2024Article
- Response to "Comment on 'Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?'".Environmental health perspectives · 2024Article
- Invited Perspective: Challenging the Dogma of Lead Neurotoxicity.Environmental health perspectives · 2023Article
- Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent?Environmental health perspectives · 2023Article
- Article
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Authors and funding
6 authors.
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Abstract
Early life lead (Pb) exposure is detrimental to neurobehavioral development. The quality of the environment can modify negative influences from Pb exposure, impacting the developmental trajectory following Pb exposure. Little is known about the molecular underpinnings in the brain of the interaction between Pb and the quality of the environment. We examined relationships between early life Pb exposure and living in an enriched versus a non-enriched postnatal environment on genome-wide transcription profiles in hippocampus CA1. RNA-seq identified differences in the transcriptome of enriched vs. non-enriched Pb-exposed animals. Most of the gene expression changes associated with Pb exposure were reversed by enrichment. This was also true for changes in upstream regulators, splicing events and long noncoding RNAs. Non-enriched rats also had memory impairments; enriched rats had no deficits. The results demonstrate that an enriched environment has a profound impact on behavior and the Pb-modified CA1 transcriptome. These findings show the potential for interactions between Pb exposure and the environment to result in significant transcriptional changes in the brain and, to the extent that this may occur in Pb-exposed children, could influence neuropsychological/educational outcomes, underscoring the importance for early intervention and environmental enrichment for Pb-exposed children.
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