SynthesisMolecular psychiatry2022
Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
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Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Genome-wide association analyses of borderline personality disorder identify 11 loci and highlight shared risk with mental and somatic disorders.Nature genetics · 2026Pooled it
- Identifying novel gene dysregulation associated with opioid overdose death: a meta-analysis of differential gene expression in human prefrontal cortex.Translational psychiatry · 2026Pooled it
- The genetics of cannabis lifetime use.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Multi-ancestry investigation of the genomics of erectile dysfunction.Nature communications · 2025Pooled it
- Genetic variation in BDNF is associated with opioid use disorder severity.Human genetics · 2026Article
- New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026Article
- Beyond total BDNF: The proBDNF/mBDNF balance in substance use disorders.Neurobiology of disease · 2026Review
- Article
- The genetics of fibromyalgia and its relationships to psychiatric and medical traits.Nature communications · 2026Article
- Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G.Nature communications · 2026Article
- Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.Addiction biology · 2026Article
- Mapping the genetic architecture of human cortical expansion and its links to neuropsychiatric disorders.bioRxiv : the preprint server for biology · 2026Article
- Investigating genetic overlap of multidimensional pain and suicidal behaviors in >2 million individuals.Research square · 2026Article
- Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps.Psychiatric genetics · 2026Review
- Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis.Psychological medicine · 2026Article
- Utilizing multimodal cortical parcellations to identify novel regions of the human cerebral cortex associated with substance use disorders.Molecular psychiatry · 2026Article
- Article
- GWAS of extended prescription analgesic use identifies genetic loci in chronic pain.Nature communications · 2026Article
- Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
33 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
20 authors.
Joseph D DeakYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-0540-6080
Hang ZhouYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7694-6391
Marco GalimbertiYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-6052-156X
Daniel F LeveyYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0001-8431-9569
Frank R WendtYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-2108-6822
Sandra Sanchez-RoigeUniversity of California San Diego, La Jolla, CA, USA.
Alexander S HatoumWashington University St. Louis Medical School, St. Louis, MO, USA.
Emma C JohnsonWashington University St. Louis Medical School, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-0394-777X
Yaira Z NunezYale School of Medicine, New Haven, CT, USA.
Ditte DemontisBiomedicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9124-2766
Anders D BørglumBiomedicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0001-8627-7219
Veera M RajagopalBiomedicine, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-5236-168X
Mariela V JenningsUniversity of California San Diego, La Jolla, CA, USA.
Rachel L KemberUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-8820-2659
Amy C JusticeYale School of Medicine, New Haven, CT, USA.
Howard J EdenbergIndiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0344-9690
Arpana AgrawalWashington University St. Louis Medical School, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0313-793X
Renato PolimantiYale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-0745-6046
Henry R KranzlerUniversity of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1018-0450
Joel GelernterYale School of Medicine, New Haven, CT, USA. joel.gelernter@yale.edu.ORCID http://orcid.org/0000-0002-4067-1859
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MAlcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7MAlcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7MSex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M7/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01DA054869 · NIDA · WASHINGTON UNIVERSITY · PI AGRAWAL, ARPANA, EDENBERG, HOWARD J · 2021 to 2025
$3.3MTranslational Research on Alcohol, Immunodeficiency, and Aging In COMpAAASU24AA022001 · NIAAA · YALE UNIVERSITY · PI BRANDT, CYNTHIA A. · 2012 to 2020
$3.2M5/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109514 · NIMH · CARDIFF UNIVERSITY · PI O'DONOVAN, MICHAEL · 2016 to 2020
$2.9MA Big Data Approach to Identify Epigenetic, Transcriptomic, and Network Dynamics as Immune Dysfunction Drivers Associated with HIV Infection and Substance Use DisorderR01DA051906 · NIDA · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER · 2020 to 2024
$2.8MBuilding Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4MInvestigating the Systems Genetics of the Patterns of Polysubstance Abuse and AddictionR33DA047527 · NIDA · YALE UNIVERSITY · PI POLIMANTI, RENATO · 2021 to 2023
$2.0MGenetics of Alcohol Dependence in African Americans: RecruitmentR01AA026364 · NIAAA · YALE UNIVERSITY · PI GELERNTER, JOEL · 2018 to 2022
$2.0MTranslational Alcohol Research Program (TARP)T32AA028259 · NIAAA · YALE UNIVERSITY · PI COSGROVE, KELLY P., VASILIOU, VASILIS · 2020 to 2024
$1.8MBLRD VA I01 BX004820CSRD VA I01 CX001734CSRD VA I01 CX001849NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA028292NIAAA NIH HHS R01 AA026364NIAAA NIH HHS T32 AA028259NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24 AA022001NIDA NIH HHS DP1 DA054394NIDA NIH HHS K02 DA032573NIDA NIH HHS R01 DA051906NIDA NIH HHS R01 DA054869NIDA NIH HHS R33 DA047527NIMH NIH HHS F32 MH122058NIMH NIH HHS U01 MH109514
Abstract
Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD to date have yielded few susceptibility loci. We performed a large-scale GWAS of OUD in individuals of European (EUR) and African (AFR) ancestry, optimizing genetic informativeness by performing MTAG (Multi-trait analysis of GWAS) with genetically correlated substance use disorders (SUDs). Meta-analysis included seven cohorts: the Million Veteran Program, Psychiatric Genomics Consortium, iPSYCH, FinnGen, Partners Biobank, BioVU, and Yale-Penn 3, resulting in a total N = 639,063 (N
Indexed as
AlcoholismOpioid-Related DisordersBlack PeopleFurinGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPhenotypePolymorphism, Single NucleotideReceptors, Opioid, muWhite PeopleFurinOPRM1 protein, humanReceptors, Opioid, mu
Identifiers
What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.