Evidence map›Paper›PMID 35879821›Full record

ArticleAsia-Pacific journal of clinical oncology2023

Physical activity behaviors in cancer survivors treated with neurotoxic chemotherapy.

David Mizrahi, David Goldstein, Terry Trinh, Tiffany Li, Hannah C Timmins, Michelle Harrison, Gavin M Marx, Elizabeth J Hovey, Craig R Lewis, Michael Friedlander and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Asia-Pacific journal of clinical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

David MizrahiThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.
David GoldsteinPrince of Wales Clinical School, UNSW Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Terry TrinhPrince of Wales Clinical School, UNSW Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Tiffany LiBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Hannah C TimminsBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
Michelle HarrisonChris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
Gavin M MarxSydney Adventist Hospital Clinical School, The University of Sydney, Sydney, New South Wales, Australia.
Elizabeth J HoveyPrince of Wales Clinical School, UNSW Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Craig R LewisPrince of Wales Clinical School, UNSW Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Michael FriedlanderPrince of Wales Clinical School, UNSW Medicine, UNSW Sydney, Sydney, New South Wales, Australia.
Susanna B ParkBrain and Mind Centre, The University of Sydney, Sydney, New South Wales, Australia.
UNSW Sydney · AUUniversity of Sydney · AUChris O’Brien Lifehouse · AUPrince of Wales Hospital · AU

Funding

Cancer Institute NSW Program 14/TBG/1-05National Health and Medical Research Council of Australia (NHMRC) 1080521NHMRC Career Development Fellowship 1148595
6 · The paper itself

Abstract

aimThere are many barriers to physical activity among cancer survivors. Survivors treated with neurotoxic chemotherapy may develop chemotherapy-induced peripheral neuropathy (CIPN) and experience additional barriers related to sensorimotor and mobility deficits. This study examined physical activity behaviors, including physical activity predictors, among cancer survivors treated with neurotoxic chemotherapies.

methodsA cross-sectional study of 252 participants, 3-24 months after neurotoxic chemotherapy, was undertaken. Physical activity was self-reported (IPAQ). CIPN was self-reported (FACT/GOG-Ntx-13), clinically graded (NCI-CTCAE), and objectively measured using neurological grading scales and neurophysiological techniques (tibial and sural nerve conduction studies). Balance (Swaymeter) and fine motor skills (grooved pegboard) were assessed. Regression models were used to identify clinical, demographic and CIPN predictors of walking and moderate-vigorous physical activity.

resultsForty-four percent of participants did not meet recommended physical activity guidelines (≥150 min/week). Sixty-six percent presented with CIPN. Nineteen percent of participants with CIPN reported that symptoms interfered with their ability to be physically active. A lower proportion of survivors aged ≥60, with grade ≥1 CIPN or BMI ≥30, reported meeting physical activity guidelines (all p < .05). Regression models identified older age, higher BMI, and patient-reported CIPN associated with lower walking, while higher BMI and females were associated with lower moderate-vigorous physical activity. Neurologically assessed CIPN did not associate with walking or moderate-vigorous physical activity.

conclusionCancer survivors exposed to neurotoxic chemotherapy have low physical activity levels. Further work should examine the factors causing physical activity limitations in this cohort and designing interventions to improve physical function and quality of life in survivors.

Indexed as

Antineoplastic AgentsCancer SurvivorsNeoplasmsPeripheral Nervous System DiseasesCross-Sectional StudiesExerciseFemaleHumansQuality of LifeAntineoplastic Agentscancerchemotherapyexerciseneurotoxicityperipheral neuropathyphysical activitysurvivorship

Identifiers

PMID35879821
PMCPMC10947250
OpenAlexW4287880015

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.