Evidence map›Paper›PMID 35880801›Full record

Trial reportDiabetes care2022

Lifestyle Intervention Strategy to Treat Diabetes in Older Adults: A Randomized Controlled Trial.

Alessandra Celli, Yoann Barnouin, Bryan Jiang, Dean Blevins, Georgia Colleluori, Sanjay Mediwala, Reina Armamento-Villareal, Clifford Qualls, Dennis T Villareal

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alessandra CelliDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Yoann BarnouinDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Bryan JiangDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Dean BlevinsDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Georgia ColleluoriDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Sanjay MediwalaDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Reina Armamento-VillarealDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.
Clifford QuallsDepartment of Mathematics and Statistics, University of New Mexico School of Medicine, Albuquerque, NM.
Dennis T VillarealDivision of Endocrinology, Diabetes, and Metabolism, Baylor College of Medicine, Houston, TX.ORCID 0000-0003-1365-7960
Michael E. DeBakey VA Medical Center · USUniversity of New Mexico · US

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · 2022 to 2025
$5.6M
NIDDK NIH HHS P30 DK020579
6 · The paper itself

Abstract

objectiveLifestyle intervention is recommended as first-line treatment of diabetes at all ages; however, little is known about the efficacy of lifestyle intervention in older adults with diabetes. We aimed to determine whether lifestyle intervention would improve glycemic control and age-relevant outcomes in older adults with diabetes and comorbidities. RESEARCH DESIGN AND

methodsA total of 100 older adults with diabetes were randomly assigned to 1-year intensive lifestyle intervention (ILI) (diet and exercise at a facility transitioned into community-fitness centers and homes) or healthy lifestyle (HL) group. The primary outcome was change in HbA1c. Secondary outcomes included glucoregulation, body composition, physical function, and quality of life. Changes between groups were analyzed with mixed-model repeated-measures ANCOVA following the intention-to-treat principle.

resultsHbA1c improved more in the ILI than the HL group (mean ± SE -0.8 ± 0.1 vs. 0.1 ± 0.1%), associated with improved insulin sensitivity (1.2 ± 0.2 vs. -0.4 ± 0.2) and disposition (26.0 ± 8.9 vs. -13.0 ± 8.4 109 min-1) indices (between-group P < 0.001 to 0.04). Body weight and visceral fat decreased more in the ILI than HL group (-8.4 ± 0.6 vs. -0.3 ± 0.6 kg, P < 0.001, and -261 ± 29 vs. -30 ± 27 cm3, P < 0.001, respectively). Physical Performance Test score increased more in the ILI than HL group (2.9 ± 0.6 vs. -0.1 ± 0.4, P < 0.001) as did VO2peak (2.2 ± 0.3 vs. -1.2 ± 0.2 mL/kg/min, P < 0.001). Strength, gait, and 36-Item Short Form Survey (SF-36) Physical Component Summary score also improved more in the ILI group (all P < 0.001). Total insulin dose decreased in the ILI group by 19.8 ± 4.4 units/day. Adverse events included increased episodes of mild hypoglycemia in the ILI group.

conclusionsA lifestyle intervention strategy is highly successful in improving metabolic and functional health of older adults with diabetes.

Indexed as

Diabetes Mellitus, Type 2Weight LossAgedGlycated HemoglobinHumansLife StyleQuality of LifeGlycated Hemoglobin

Identifiers

PMID35880801
PMCPMC9472494
OpenAlexW4288010115

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.