Evidence map›Paper›PMID 35882452›Full record

ArticleBMJ open2022

Gestational diabetes mellitus and offspring's carotid intima-media thickness at birth: MySweetHeart Cohort study.

Adina Mihaela Epure, Stefano Di Bernardo, Yvan Mivelaz, Sandrine Estoppey Younes, Arnaud Chiolero, Nicole Sekarski, MySweetHeart Research Group

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02872974 (Consequences of Maternal Gestational Diabetes on Offspring's Cardiovascular Health), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02872974 completednot on this map

Consequences of Maternal Gestational Diabetes on Offspring's Cardiovascular Health: MySweetHeart Cohort

TypeobservationalSponsorUniversity of Lausanne HospitalsRan2016 to 2020Enrolled200ConditionsCardiovascular Diseases, Gestational Diabetes MellitusArmsGDM
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Adina Mihaela EpurePopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland.ORCID 0000-0002-8104-0244
Stefano Di BernardoPaediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0003-1977-3727
Yvan MivelazPaediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland.ORCID 0000-0002-3507-6879
Sandrine Estoppey YounesDepartment of Epidemiology and Health Services, Center for Primary Care and Public Health (UNISANTÉ), University of Lausanne, Lausanne, Switzerland.
Arnaud Chiolero *Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland.ORCID 0000-0002-5544-8510
Nicole Sekarski *Paediatric Cardiology Unit, Woman-Mother-Child Department, Lausanne University Hospital (CHUV), Lausanne, Switzerland nicole.sekarski@chuv.ch.ORCID 0000-0002-3269-249X
MySweetHeart Research Group
University of Lausanne · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHUniversity Hospital of Lausanne · CHUniversity of Bern · CHUniversity of Fribourg · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveHyperglycaemia during pregnancy is associated with cardiometabolic risks for the mother and the offspring. Mothers with gestational diabetes mellitus (GDM) have signs of subclinical atherosclerosis, including increased carotid intima-media thickness (CIMT). We assessed whether GDM is associated with increased CIMT in the offspring at birth. DESIGN AND

settingMySweetHeart Cohort is a prospective cohort study conducted in Switzerland. PARTICIPANTS, EXPOSURE AND OUTCOME MEASURES: This work included pregnant women with and without GDM at 24-32 weeks of gestation and their singleton live-born offspring with data on the primary outcome of CIMT. GDM was diagnosed based on the criteria of the International Association of Diabetes and Pregnancy Study Groups. Offspring's CIMT was measured by ultrasonography after birth (range 1-19 days).

resultsData on CIMT were available for 99 offspring of women without GDM and 101 offspring of women with GDM. Maternal age ranged from 18 to 47 years. Some 16% of women with GDM and 6% of women without GDM were obese. Smoking during pregnancy was more frequent among women with GDM (18%) than among those without GDM (4%). Neonatal characteristics were comparable between the two groups. The difference in CIMT between offspring of women with and without GDM was of 0.00 mm (95% CI -0.01 to 0.01; p=0.96) and remained similar on adjustment for potential confounding factors, such as maternal prepregnancy body mass index, maternal education, smoking during pregnancy, family history of diabetes, as well as offspring's sex, age, and body surface area (0.00 mm (95% CI -0.02 to 0.01; p=0.45)).

conclusionsWe found no evidence of increased CIMT in neonates exposed to GDM. A longer-term follow-up that includes additional vascular measures, such as endothelial function or arterial stiffness, may shed further light on the cardiovascular health trajectories in children born to mothers with GDM. TRIAL REGISTRATION NUMBER: NCT02872974; Pre-results.

Indexed as

Diabetes, GestationalAdolescentAdultBody Mass IndexCarotid Intima-Media ThicknessChildCohort StudiesFemaleHumansInfant, NewbornMiddle AgedPregnancyProspective StudiesYoung Adultcardiac epidemiologycardiovascular imagingdiabetes in pregnancyneonatologypaediatric cardiology

Identifiers

PMID35882452
PMCPMC9330339
OpenAlexW4288180054

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.