ArticleAntibiotics (Basel, Switzerland)2022
Mining Amphibian and Insect Transcriptomes for Antimicrobial Peptide Sequences with rAMPage.
Article in Antibiotics (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Efficacy and safety evaluation of artificial intelligence-identified antimicrobial peptides targeting avian pathogenic Escherichia coli in broiler chickens.Journal of animal science and biotechnology · 2026Article
- Mining the UniProtKB/Swiss-Prot database for antimicrobial peptides.Protein science : a publication of the Protein Society · 2025Article
- Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance.Pharmaceutics · 2024Review
- De novo synthetic antimicrobial peptide design with a recurrent neural network.Protein science : a publication of the Protein Society · 2024Article
- Structure-aware deep learning model for peptide toxicity prediction.Protein science : a publication of the Protein Society · 2024Article
- Heterologous Production of Antimicrobial Peptides: Notes to Consider.The protein journal · 2024Article
- Article
- The Expression of Antibacterial Peptide Turgencin A inMolecules (Basel, Switzerland) · 2023Article
- A 2022 Update on Computational Approaches to the Discovery and Design of Antimicrobial Peptides.Antibiotics (Basel, Switzerland) · 2023Article
- Peptidomics.Nature reviews. Methods primers · 2023Article
- Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects.Antibiotics (Basel, Switzerland) · 2022Article
- 'Targeting' the search: An upgraded structural and functional repository of antimicrobial peptides for biofilm studies (B-AMP v2.0) with a focus on biofilm protein targets.Frontiers in cellular and infection microbiology · 2022Article
- Deep learning tools to accelerate antibiotic discovery.Expert opinion on drug discoveryReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Antibiotic resistance is a global health crisis increasing in prevalence every day. To combat this crisis, alternative antimicrobial therapeutics are urgently needed. Antimicrobial peptides (AMPs), a family of short defense proteins, are produced naturally by all organisms and hold great potential as effective alternatives to small molecule antibiotics. Here, we present rAMPage, a scalable bioinformatics discovery platform for identifying AMP sequences from RNA sequencing (RNA-seq) datasets. In our study, we demonstrate the utility and scalability of rAMPage, running it on 84 publicly available RNA-seq datasets from 75 amphibian and insect species-species known to have rich AMP repertoires. Across these datasets, we identified 1137 putative AMPs, 1024 of which were deemed novel by a homology search in cataloged AMPs in public databases. We selected 21 peptide sequences from this set for antimicrobial susceptibility testing against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.