Evidence map›Paper›PMID 35884276›Full record

ReviewBiosensors2022

Utilizing Electrochemical-Based Sensing Approaches for the Detection of SARS-CoV-2 in Clinical Samples: A Review.

Nor Syafirah Zambry, Godwin Attah Obande, Muhammad Fazli Khalid, Yazmin Bustami, Hairul Hisham Hamzah, Mohd Syafiq Awang, Ismail Aziah, Asrulnizam Abd Manaf

Open access · goldAbstract readReview
In one paragraph

Review in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Protein Stacking on the APTES-Functionalized Pyrochlore BiACS applied materials & interfaces · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Nor Syafirah ZambryInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0002-1637-2285
Godwin Attah ObandeDepartment of Medical Microbiology and Parasitology, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0002-3974-9196
Muhammad Fazli KhalidInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0003-2053-0546
Yazmin BustamiSchool of Biological Sciences, Universiti Sains Malaysia, Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0001-6556-0082
Hairul Hisham HamzahSchool of Chemical Sciences, Universiti Sains Malaysia, Gelugor 11800, Pulau Pinang, Malaysia.ORCID 0000-0002-8296-1360
Mohd Syafiq AwangCollaborative Microelectronic Design Excellence Centre (CEDEC), Sains@USM, Universiti Sains Malaysia, Bayan Lepas 11900, Pulau Pinang, Malaysia.ORCID 0000-0001-7998-8354
Ismail AziahInstitute for Research in Molecular Medicine (INFORMM), Health Campus, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia.ORCID 0000-0001-7850-6405
Asrulnizam Abd ManafCollaborative Microelectronic Design Excellence Centre (CEDEC), Sains@USM, Universiti Sains Malaysia, Bayan Lepas 11900, Pulau Pinang, Malaysia.ORCID 0000-0002-6198-263X
Universiti Sains Malaysia · MY

Funding

Higher Institution Centre of Excellence (HICoE) Grant 311/CIPPM/4401005Research University Grant USM 1001/CIPPM/8012383Top Down Research University Grant 1001/PCEDEC/870050
6 · The paper itself

Abstract

The development of precise and efficient diagnostic tools enables early treatment and proper isolation of infected individuals, hence limiting the spread of coronavirus disease 2019 (COVID-19). The standard diagnostic tests used by healthcare workers to diagnose severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have some limitations, including longer detection time, the need for qualified individuals, and the use of sophisticated bench-top equipment, which limit their use for rapid SARS-CoV-2 assessment. Advances in sensor technology have renewed the interest in electrochemical biosensors miniaturization, which provide improved diagnostic qualities such as rapid response, simplicity of operation, portability, and readiness for on-site screening of infection. This review gives a condensed overview of the current electrochemical sensing platform strategies for SARS-CoV-2 detection in clinical samples. The fundamentals of fabricating electrochemical biosensors, such as the chosen electrode materials, electrochemical transducing techniques, and sensitive biorecognition molecules, are thoroughly discussed in this paper. Furthermore, we summarised electrochemical biosensors detection strategies and their analytical performance on diverse clinical samples, including saliva, blood, and nasopharyngeal swab. Finally, we address the employment of miniaturized electrochemical biosensors integrated with microfluidic technology in viral electrochemical biosensors, emphasizing its potential for on-site diagnostics applications.

Indexed as

Biosensing TechniquesCOVID-19COVID-19 TestingElectrochemical TechniquesHumansSARS-CoV-2COVID-19diagnostic methodselectrochemical biosensormicrofluidic electrochemical devicesminiaturised electrochemical sensorpoint of care (POC)SARS-CoV-2

Identifiers

PMID35884276
PMCPMC9312918
OpenAlexW4283728659

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.