ArticleBiomedicines2022
Analysis of Purine Metabolism to Elucidate the Pathogenesis of Acute Kidney Injury in Renal Hypouricemia.
Article in Biomedicines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Serum Metabolomic Signatures of Iron Deficiency Anemia: An Untargeted LC-HRMS-Based Case-Control Study.Anemia · 2026Article
- Annual change in eGFR in renal hypouricemia: a retrospective pilot study.Clinical and experimental nephrology · 2025Article
- Unmasking the silent culprit: recurrent exercise-induced acute kidney injury in a Chinese adolescent with renal hypouricemia.Renal failure · 2024Article
- Genotype and Phenotype of Renal Hypouricemia: A Single-Center Study from China.Molecular diagnosis & therapy · 2024Article
- Renal hypouricemia complicated with kidney stone: a case report.Frontiers in medicine · 2024Article
- Recurrent exercise-induced acute kidney injury associated with hypouricemia: a case report and literature review.BMC nephrology · 2023Review
- Possible Use of Non-purine Selective Xanthine Oxidoreductase Inhibitors for Prevention of Exercise-induced Acute Kidney Injury Associated with Renal Hypouricemia.Internal medicine (Tokyo, Japan) · 2023Article
- Renal hypouricemia as the cause of exercise-induced acute kidney injury.Kidney research and clinical practice · 2023Article
- Clinical features suggesting renal hypouricemia as the cause of acute kidney injury: a case report and review of the literature.Journal of nephrology · 2023Review
- SLC2A9 rs16890979 reduces uric acid absorption by kidney organoids.Frontiers in cell and developmental biology · 2023Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal hypouricemia is a disease caused by the dysfunction of renal urate transporters. This disease is known to cause exercise-induced acute kidney injury, but its mechanism has not yet been established. To analyze the mechanism by which hypouricemia causes renal failure, we conducted a semi-ischemic forearm exercise stress test to mimic exercise conditions in five healthy subjects, six patients with renal hypouricemia, and one patient with xanthinuria and analyzed the changes in purine metabolites. The results showed that the subjects with renal hypouricemia had significantly lower blood hypoxanthine levels and increased urinary hypoxanthine excretion after exercise than healthy subjects. Oxidative stress markers did not differ between healthy subjects and hypouricemic subjects before and after exercise, and no effect of uric acid as a radical scavenger was observed. As hypoxanthine is a precursor for adenosine triphosphate (ATP) production via the salvage pathway, loss of hypoxanthine after exercise in patients with renal hypouricemia may cause ATP loss in the renal tubules and consequent tissue damage.
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