Evidence map›Paper›PMID 35886017›Full record

ReviewGenes2022

Leukocyte Telomere Length as a Molecular Biomarker of Coronary Heart Disease.

Olga V Zimnitskaya, Marina M Petrova, Natalia V Lareva, Marina S Cherniaeva, Mustafa Al-Zamil, Anastasia E Ivanova, Natalia A Shnayder

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Olga V ZimnitskayaDepartment of Outpatient Therapy and General Practice with Course of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.
Marina M PetrovaDepartment of Outpatient Therapy and General Practice with Course of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.
Natalia V LarevaDepartment of Therapy, Faculty of Postgraduate Education, Chita State Medical Academy, 672000 Chita, Russia.
Marina S CherniaevaDepartment of Internal and Preventive Medicine, Central State Medical Academy of the Presidential Administration, 121359 Moscow, Russia.ORCID 0000-0003-3091-7904
Mustafa Al-ZamilDepartment of Physiotherapy, Faculty of Continuing Medical Education, Peoples' Friendship University of Russia, 117198 Moscow, Russia.ORCID 0000-0002-3643-982X
Anastasia E IvanovaV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, Institute of Personalized Psychiatry and Neurology, 192019 St. Petersburg, Russia.
Natalia A ShnayderDepartment of Outpatient Therapy and General Practice with Course of Postgraduate Education, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia.ORCID 0000-0002-2840-837X
Krasnoyarsk State Medical University · RUSt.Petersburg V.M.Bekhterev Psychoneurological Research Institute · RUCentral State Medical Academy · RUChita State Academy of Medicine · RUPeoples' Friendship University of Russia · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis work is a review of preclinical and clinical studies of the role of telomeres and telomerase in the development and progression of coronary heart disease (CHD). MATERIALS AND

methodsA search for full-text publications (articles, reviews, meta-analyses, Cochrane reviews, and clinical cases) in English and Russian was carried out in the databases PubMed, Oxford University Press, Scopus, Web of Science, Springer, and E-library electronic library using keywords and their combinations. The search depth is 11 years (2010-2021).

resultsThe review suggests that the relative leukocyte telomere length (LTL) is associated with the development of socially significant and widespread cardiovascular diseases such as CHD and essential hypertension. At the same time, the interests of researchers are mainly focused on the study of the relative LTL in CHD.

conclusionsDespite the scientific and clinical significance of the analyzed studies of the relative length of human LTL as a biological marker of cardiovascular diseases, their implementation in real clinical practice is difficult due to differences in the design and methodology of the analyzed studies, as well as differences in the samples by gender, age, race, and ethnicity. The authors believe that clinical studies of the role of the relative length of leukocyte telomeres in adult patients with coronary heart disease are the most promising and require large multicenter studies with a unified design and methodology.

Indexed as

Cardiovascular DiseasesCoronary DiseaseAdultBiomarkersHumansLeukocytesTelomereBiomarkersacute coronary syndromeacute myocardial infarctionadultscoronary atherosclerosisearly vascular agingmolecular predictorspeoplestable coronary heart diseasetelomere length

Identifiers

PMID35886017
PMCPMC9318544
OpenAlexW4285091448

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.